Strain Data Sheet

RBRC01059

Strain Information

Image
BRC No.RBRC01059
TypeInbred
SpeciesMus musculus
Strain nameNC
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearanceagouti brown [A/A b/b C/C D/D S/S]
Strain developmentDeveloped by Dr. Kyoji Kondo at Nagoya University, School of Agriculture. Derived from a cinnamon coat color colony of Japanese fancy mice (Nishiki-Nezumi).
Strain descriptionNC/Nga mice were originated from Japanese fancy mice (Nishiki-Nezumi) and were established as a inbred strain in 1955. NC/Nga mice develop skin lesions similar to atopic dermatitis when kept under conventional environment, but not under specific pathogen -free environment as specific pathogen-free animals. They also show a high susceptibility to X-irradiation and anaphylactic shock from ovalbumin. Developed by Dr. Kyoji Kondo at Nagoya University.
Colony maintenanceSibling Mating
References
JIkken Doubutsu, 6, 107-112 (1957).

Health Report

Examination Date / Room / Rack2024/08/26Room:4-BRack:J
2024/05/27Room:4-BRack:J
2024/02/26Room:4-BRack:J
2023/11/27Room:4-BRack:J
2023/08/28Room:4-BRack:J
2023/05/29Room:4-BRack:J
2023/02/27Room:4-BRack:J

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Derm1dermatitis 19Derm1NC/Nga

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • dermatitis(MP:0001194)

  • increased cellular sensitivity to X-ray irradiation(MP:0002879)

  • skin lesions(MP:0001212)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDermatology Research
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorTakao Namikawa (Nagoya University)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    Strain AvailabilityCryopreserved embryos (within 1 month)
    Live mouse (1 to 3 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    Chiu YH, Wu YW, Hung JI, Chen MC.
    Epigallocatechin gallate/L-ascorbic acid-loaded poly-γ-glutamate microneedles with antioxidant, anti-inflammatory, and immunomodulatory effects for the treatment of atopic dermatitis.
    Acta Biomater 130 223-233(2021) 34087444
    Chen MC, Chen CS, Wu YW, Yang YY.
    Poly-γ-Glutamate microneedles as transdermal immunomodulators for ameliorating atopic dermatitis-like skin lesions in Nc/Nga mice.
    Acta Biomater 114 183-192(2020) 32688089
    F Zhuo, MAS Abourehab, Z Hussain.
    Hyaluronic Acid Decorated Tacrolimus-Loaded Nanoparticles: Efficient Approach to Maximize Dermal Targeting and Anti-dermatitis Efficacy.
    Carbohydrate Polymers ()
    Hussain Z, Katas H, Mohd Amin MC, Kumolosasi E, Buang F, Sahudin S.
    Self-assembled polymeric nanoparticles for percutaneous co-delivery of hydrocortisone/hydroxytyrosol: an ex vivo and in vivo study using an NC/Nga mouse model.
    Int J Pharm 444(1-2) 109-19(2013) 23337632
    Hussain Z, Katas H, Amin MC, Kumulosasi E, Sahudin S.
    Antidermatitic perspective of hydrocortisone as chitosan nanocarriers: an ex vivo and in vivo assessment using an NC/Nga mouse model.
    J Pharm Sci 102(3) 1063-75(2013) 23303620
    Knitlova J, Hajkova V, Voska L, Elsterova J, Obrova B, Melkova Z.
    Development of eczema vaccinatum in atopic mouse models and efficacy of MVA vaccination against lethal poxviral infection.
    PLoS One 9(12) e114374(2014) 25486419
    Hussain Z, Katas H, Mohd Amin MC, Kumolosasi E.
    Efficient immuno-modulation of TH1/TH2 biomarkers in 2,4-dinitrofluorobenzene-induced atopic dermatitis: nanocarrier-mediated transcutaneous co-delivery of anti-inflammatory and antioxidant drugs.
    PLoS One 9(11) e113143(2014) 25396426
    Yang Z, Liu M, Wang W, Wang Y, Cao B, Gao Y, Chen H, Li T.
    Pseudolaric acid B attenuates atopic dermatitis-like skin lesions by inhibiting interleukin-17-induced inflammation.
    Sci Rep 7(1) 7918(2017) 28801611