Strain Data Sheet

RBRC01057

Strain Information

Image
BRC No.RBRC01057
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC57BL/6-Nrp1<tmHfu>
Former Common nameC57BL/6-Nrp1<tmHfu>
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainC57BL/6NCrSlc
Appearanceblack [a/a B/B C/C]
Strain developmentこのマウス系統は、1997年に名古屋大学大学院理学研究科の藤澤肇先生と大学共同利用機関法人自然科学研究機構生理学研究所の八木健先生によって開発された。
Strain description神経線維の投射異常、神経細胞の移動異常、心臓・血管系の形成異常があり、神経形成、血管形成の制御、免疫系の解析にも適す。
Colony maintenance特になし。
References
Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice.
T Kitsukawa, M Shimizu, M Sanbo, T Hirata, M Taniguchi, Y Bekku, T Yagi, H Fujisawa
Neuron, 19, 995-1005 (1997). 9390514

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Nrp1
MGI:106206		neuropilin 18Nrp1<tm1Hfu>
MGI:1857853		targeted mutation 1, Hajime Fujisawa
neo neomycin resistance gene (E. coli)8 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal aortic arch and aortic arch branch attachment (MP:0010464)

  • abnormal axon guidance (MP:0002961)

  • abnormal dorsal aorta morphology (MP:0004787)

  • abnormal facial motor nucleus morphology (MP:0000909)

  • abnormal facial nerve morphology (MP:0001071)
    • more 18 phenotypes
  • abnormal first pharyngeal arch artery morphology (MP:0010355)

  • abnormal fourth pharyngeal arch artery morphology (MP:0006354)

  • abnormal pharyngeal arch artery morphology (MP:0002672)

  • abnormal pulmonary artery morphology (MP:0000484)

  • abnormal second pharyngeal arch artery morphology (MP:0010356)

  • abnormal sixth pharyngeal arch artery morphology (MP:0006355)

  • abnormal spinal nerve morphology (MP:0001077)

  • abnormal third pharyngeal arch artery morphology (MP:0006356)

  • abnormal trigeminal nerve morphology (MP:0001065)

  • abnormal vascular development (MP:0000259)

  • decreased angiogenesis (MP:0005602)

  • disorganized yolk sac vascular plexus (MP:0001723)

  • double aortic arch (MP:0004159)

  • embryonic lethality during organogenesis, complete penetrance (MP:0011098)

  • embryonic lethality, complete penetrance (MP:0011092)

  • persistent truncus arteriosus (MP:0002633)

  • right aortic arch (MP:0004158)

  • transposition of great arteries (MP:0004110)
    • Detailed phenotype data

    Ordering Information

    供与核酸herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, SV40 poly A, mouse C57BL/6 Neuropilin-1 genomic DNA
    Research applicationCardiovascular Research
    Developmental Biology Research
    Hematological Research
    Immunology and Inflammation Research
    Neurobiology Research
    covid19_infection
    提供条件研究成果の公表にあたって寄託者の指定する文献を引用する。Neuron, 19, 995-1005 (1997).
    Depositor藤澤　肇（名古屋大学）
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data