Strain Data Sheet

RBRC01055

Strain Information

Image
BRC No.RBRC01055
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6;129P2-Ski<tm1Cco>
Former Common nameSki Knockout mouse
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strainC57BL/6NJcl
Appearance
Strain developmentDr. Clemencia Colmenares
Strain descriptionホモは致死。
Colony maintenance繁殖率が低下してきているので、 back crossは控えてほしい。同居の雌はC57BL/6N。
References
Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development.
M Berk, S Y Desai, H C Heyman, C Colmenares
Genes Dev., 11, 2029-2039 (1997). 9284043

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ski
MGI:98310		ski sarcoma viral oncogene homolog (avian)4Ski<tm1Cco>
MGI:2177555		targeted mutation 1, Clemencia Colmenares
  • Shprintzen-Goldberg syndrome(MedGEN)
    • neo neomycin resistance gene (E. coli)4 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal cervical atlas morphology (MP:0004607)

  • abnormal cervical axis morphology (MP:0004608)

  • abnormal cervical vertebrae morphology (MP:0003048)

  • abnormal ectomesenchyme morphology (MP:0006302)

  • abnormal forebrain morphology (MP:0000783)
    • more 35 phenotypes
  • abnormal jaw morphology (MP:0000454)

  • abnormal neural tube morphology (MP:0002151)

  • abnormal neurocranium morphology (MP:0000074)

  • abnormal olfactory bulb morphology (MP:0000819)

  • abnormal paraxial mesoderm morphology (MP:0008029)

  • abnormal presphenoid bone morphology (MP:0004448)

  • abnormal skeletal muscle fiber morphology (MP:0003084)

  • abnormal skeletal muscle morphology (MP:0000759)

  • abnormal skeleton development (MP:0002113)

  • abnormal spine curvature (MP:0004174)

  • absent frontal bone (MP:0004376)

  • absent interparietal bone (MP:0004383)

  • absent parietal bone (MP:0004419)

  • decreased fetal size (MP:0004200)

  • decreased skeletal muscle fiber diameter (MP:0009402)

  • decreased skeletal muscle mass (MP:0004819)

  • exencephaly (MP:0000914)

  • eyelids open at birth (MP:0001302)

  • flat face (MP:0012175)

  • hemorrhage (MP:0001914)

  • increased fibroblast proliferation (MP:0011703)

  • increased incidence of tumors by chemical induction (MP:0004499)

  • increased lymphoma incidence (MP:0012431)

  • lethality throughout fetal growth and development, incomplete penetrance (MP:0011109)

  • mandibular hyperostosis (MP:0030223)

  • midline facial cleft (MP:0000108)

  • muscle hypoplasia (MP:0000734)

  • open neural tube (MP:0000929)

  • perinatal lethality, complete penetrance (MP:0011089)

  • polydactyly (MP:0000562)

  • short mandible (MP:0000088)

  • shortened head (MP:0000435)

  • small basioccipital bone (MP:0004447)

  • small basisphenoid bone (MP:0004462)

  • vertebral transformation (MP:0003036)
    • Detailed phenotype data

    Ordering Information

    供与核酸E. coli neo, mouse Sloan-Ketterong viral oncongene homolog genome DNA, herpes simplex virus thymidine kinase promoter (HSV tk promoter)
    Research applicationDevelopmental Biology Research
    提供条件利用者は事前に寄託者の提供承諾書を得る。研究成果の公表にあたって寄託者の指定する文献を引用する。Genes Dev., 11, 2029-2039 (1997). 研究成果の公表にあたって謝辞の表明を必要とする。The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.
    DepositorClemencia Colmenares（The Cleveland Clinic Foundation）
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data