Strain Data Sheet

RBRC01055

Strain Information

Image
BRC No.RBRC01055
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6;129P2-Ski<tm1Cco>
Former Common nameSki Knockout mouse
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strainC57BL/6NJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development.
Berk M, Desai S Y, Heyman H C, Colmenares C
Genes Dev., 11, 2029-2039 (1997). 9284043

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Skiski sarcoma viral oncogene homolog (avian)4Skitargeted mutation 1, Clemencia Colmenares
  • Shprintzen-Goldberg syndrome(MedGEN)
  • neoneomycin resistance gene (E. coli)4herpes simplex virus thymidine kinase promoter (HSV tk promoter)
  • Shprintzen-Goldberg syndrome(MedGEN)
  • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal cervical atlas morphology(MP:0004607)

  • abnormal cervical axis morphology(MP:0004608)

  • abnormal cervical vertebrae morphology(MP:0003048)

  • abnormal ectomesenchyme morphology(MP:0006302)

  • abnormal forebrain morphology(MP:0000783)
  • more 35 phenotypes
  • abnormal jaw morphology(MP:0000454)

  • abnormal neural tube morphology(MP:0002151)

  • abnormal neurocranium morphology(MP:0000074)

  • abnormal olfactory bulb morphology(MP:0000819)

  • abnormal paraxial mesoderm morphology(MP:0008029)

  • abnormal presphenoid bone morphology(MP:0004448)

  • abnormal skeletal muscle fiber morphology(MP:0003084)

  • abnormal skeletal muscle morphology(MP:0000759)

  • abnormal skeleton development(MP:0002113)

  • abnormal spine curvature(MP:0004174)

  • absent frontal bone(MP:0004376)

  • absent interparietal bone(MP:0004383)

  • absent parietal bone(MP:0004419)

  • decreased fetal size(MP:0004200)

  • decreased skeletal muscle fiber diameter(MP:0009402)

  • decreased skeletal muscle mass(MP:0004819)

  • exencephaly(MP:0000914)

  • eyelids open at birth(MP:0001302)

  • flat face(MP:0012175)

  • hemorrhage(MP:0001914)

  • increased fibroblast proliferation(MP:0011703)

  • increased incidence of tumors by chemical induction(MP:0004499)

  • increased lymphoma incidence(MP:0012431)

  • lethality throughout fetal growth and development, incomplete penetrance(MP:0011109)

  • mandibular hyperostosis(MP:0030223)

  • midline facial cleft(MP:0000108)

  • muscle hypoplasia(MP:0000734)

  • open neural tube(MP:0000929)

  • perinatal lethality, complete penetrance(MP:0011089)

  • polydactyly(MP:0000562)

  • short mandible(MP:0000088)

  • shortened head(MP:0000435)

  • small basioccipital bone(MP:0004447)

  • small basisphenoid bone(MP:0004462)

  • vertebral transformation(MP:0003036)
  • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli neo, mouse Sloan-Ketterong viral oncongene homolog genome DNA, herpes simplex virus thymidine kinase promoter (HSV tk promoter)
    Research applicationDevelopmental Biology Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Dev., 11, 2029-2039 (1997). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.
    DepositorClemencia Colmenares (The Cleveland Clinic Foundation)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data