Strain Data Sheet

RBRC01054

Strain Information

Image
BRC No.RBRC01054
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameC.Cg-Skil<tm1Sis>/Rbrc
Former Common nameSno Knockout mouse
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainBALB/cByJJcl
Appearance
Strain development
Strain descriptionホモは致死。
Colony maintenance
References
The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice.
T Shinagawa, H D Dong, M Xu, T Maekawa, S Ishii
EMBO J., 19, 2280-2291 (2000). 10811619

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Skil
MGI:106203		SKI-like3Skil<tm1Sis>
MGI:2387096		targeted mutation 1, Shunsuke Ishii
neo neomycin resistance gene (E. coli)3

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • cachexia (MP:0005150)

  • embryonic lethality before implantation, complete penetrance (MP:0011094)

  • failure of zygotic cell division (MP:0003406)

  • increased B cell derived lymphoma incidence (MP:0002023)

  • increased T cell derived lymphoma incidence (MP:0002024)
    • more 2 phenotypes
  • increased incidence of tumors by chemical induction (MP:0004499)

  • increased susceptibility to xenobiotic induced morbidity/mortality (MP:0009766)
    • Detailed phenotype data

    Ordering Information

    供与核酸E. coli neo, mouse Sno genome DNA
    Research application
    提供条件研究成果の公表にあたって譲渡者の指定する文献を引用する。EMBO J., 19, 2280-2291 (2000).研究成果の公表にあたって謝辞の表明を必要とする。
    Depositor石井　俊輔（独立行政法人理化学研究所）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data