Strain Data Sheet

RBRC01054

update : 2025-03-19

Strain Information
Image
BRC No.	RBRC01054
Type	Targeted Mutation Congenic
Species	Mus musculus
Strain name	C.Cg-Skil<tm1Sis>/Rbrc
Former Common name	Sno Knockout mouse
H-2 Haplotype
ES Cell line	TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain	BALB/cByJJcl
Appearance
Strain development
Strain description
Colony maintenance
References	The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice. Shinagawa T, Dong H D, Xu M, Maekawa T, Ishii S EMBO J., 19, 2280-2291 (2000). 10811619

Health Report
Examination Date / Room / Rack

Gene
Gene Symbol	Gene Name	Chr.	Allele Symbol	Allele Name	Common Names	Promoter	Diseases Related to This Gene
Skil MGI:106203	SKI-like	3	Skil<tm1Sis> MGI:2387096	targeted mutation 1, Shunsuke Ishii
neo	neomycin resistance gene (E. coli)	3

Phenotype
Annotation by Mammalian phenotyhpe ontology	cachexia(MP:0005150) embryonic lethality before implantation, complete penetrance(MP:0011094) failure of zygotic cell division(MP:0003406) increased B cell derived lymphoma incidence(MP:0002023) increased T cell derived lymphoma incidence(MP:0002024) more 2 phenotypes increased incidence of tumors by chemical induction(MP:0004499) increased susceptibility to xenobiotic induced morbidity/mortality(MP:0009766)
Detailed phenotype data

Annotation by Mammalian phenotyhpe ontology

embryonic lethality before implantation, complete penetrance(MP:0011094)

failure of zygotic cell division(MP:0003406)

increased B cell derived lymphoma incidence(MP:0002023)

increased T cell derived lymphoma incidence(MP:0002024)

more 2 phenotypes

increased incidence of tumors by chemical induction(MP:0004499)

increased susceptibility to xenobiotic induced morbidity/mortality(MP:0009766)

Detailed phenotype data

Ordering Information
Donor DNA	E. coli neo, mouse Sno genome DNA
Research application
Specific Term and Conditions	In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. EMBO J., 19, 2280-2291 (2000).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Depositor	Shunsuke Ishii (RIKEN)
Strain Status	Frozen embryos
Strain Availability	Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month)
Additional Info.	Necessary documents for ordering: Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English) Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data