Strain Data Sheet

RBRC01046

Strain Information

Image
BRC No.RBRC01046
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Atf2<tm1Sis>/Rbrc
Former Common nameATF2o Knock out (CRE-BP1)-B6
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearanceblack [a/a B/B C/C]
Strain development開発年：1999年開発者：前川利男先生機関名：理化学研究所　分子遺伝学研究室B6 94%, CBA 6%　10代以上
Strain descriptionhomoはlethal
Colony maintenance良好homoはlethal
References
Mouse ATF-2 null mutants display features of a severe type of meconium aspiration syndrome.
Maekawa T, Bernier F, Sato M, Nomura S, Singh M, Inoue Y, Tokunaga T, Imai H, Yokoyama M, Reimold A, Glimcher L H, Ishii S
J. Biol. Chem., 274, 17813-17819 (1999). 10364225

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Atf2
MGI:109349		activating transcription factor 22Atf2<tm1Sis>
MGI:1857283		targeted mutation 1, Laurie Glimcher
neo neomycin resistance gene (E. coli)2 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal lung morphology (MP:0001175)

  • abnormal placenta labyrinth morphology (MP:0001716)

  • abnormal placenta vasculature (MP:0003231)

  • cyanosis (MP:0001575)

  • hypoxia (MP:0005039)
    • more 2 phenotypes
  • neonatal lethality, complete penetrance (MP:0011087)

  • respiratory failure (MP:0001953)
    • Detailed phenotype data

    Ordering Information

    供与核酸mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse activating transcription factor 2 genomic DNA
    Research applicationCell Biology Research
    提供条件研究成果の公表にあたって譲渡者の指定する文献を引用する。J. Biol. Chem., 274, 17813-17819 (1999). 研究成果の公表にあたって謝辞の表明を必要とする。
    Depositor石井　俊輔（独立行政法人理化学研究所）
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data