Strain Data Sheet

RBRC01046

Strain Information

Image
BRC No.RBRC01046
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Atf2<tm1Sis>/Rbrc
Former Common nameATF2o Knock out (CRE-BP1)-B6
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Drs. Toshio Maekawa and Shunsuke Ishii, RIKEN Tsukuba Institute in 1999.
Strain descriptionATF2 (CRE-BP1) is a transcription factor of the ATF/CREB family. This protein has a zinc finger structure as a transactivation domain located at the amino terminus and a leucin zipper motif, and phosphorylated by the stress-activated protein kinase such as the Jun amino-terminal kinase and p38. ATF2 deficient mice die shortly after birth and display symptoms of severe respiratory distress with lungs filled with meconium. This strain is useful as an animal model for meconium aspiration syndrome (MAS).
Colony maintenanceBackcross to C57BL/6 (Heterozygote x C57BL/6JJcl)
References
Mouse ATF-2 null mutants display features of a severe type of meconium aspiration syndrome.
Maekawa T, Bernier F, Sato M, Nomura S, Singh M, Inoue Y, Tokunaga T, Imai H, Yokoyama M, Reimold A, Glimcher L H, Ishii S
J. Biol. Chem., 274, 17813-17819 (1999). 10364225

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Atf2
MGI:109349		activating transcription factor 22Atf2<tm1Sis>
MGI:1857283		targeted mutation 1, Laurie Glimcher
neo neomycin resistance gene (E. coli)2 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal lung morphology (MP:0001175)

  • abnormal placenta labyrinth morphology (MP:0001716)

  • abnormal placenta vasculature (MP:0003231)

  • cyanosis (MP:0001575)

  • hypoxia (MP:0005039)
    • more 2 phenotypes
  • neonatal lethality, complete penetrance (MP:0011087)

  • respiratory failure (MP:0001953)
    • Detailed phenotype data

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    BRC mice in Publications

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