Strain Information | |
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Image | |
BRC No. | RBRC01046 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.Cg-Atf2<tm1Sis>/Rbrc |
Former Common name | ATF2o Knock out (CRE-BP1)-B6 |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Drs. Toshio Maekawa and Shunsuke Ishii, RIKEN Tsukuba Institute in 1999. |
Strain description | ATF2 (CRE-BP1) is a transcription factor of the ATF/CREB family. This protein has a zinc finger structure as a transactivation domain located at the amino terminus and a leucin zipper motif, and phosphorylated by the stress-activated protein kinase such as the Jun amino-terminal kinase and p38. ATF2 deficient mice die shortly after birth and display symptoms of severe respiratory distress with lungs filled with meconium. This strain is useful as an animal model for meconium aspiration syndrome (MAS). |
Colony maintenance | Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl) |
References | Mouse ATF-2 null mutants display features of a severe type of meconium aspiration syndrome. Maekawa T, Bernier F, Sato M, Nomura S, Singh M, Inoue Y, Tokunaga T, Imai H, Yokoyama M, Reimold A, Glimcher L H, Ishii S J. Biol. Chem., 274, 17813-17819 (1999). 10364225 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Atf2 | activating transcription factor 2 | 2 | Atf2 | targeted mutation 1, Laurie Glimcher | |||
neo | neomycin resistance gene (E. coli) | 2 | mouse phosphoglycerate kinase promoter (PGK promoter) |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse activating transcription factor 2 genomic DNA |
Research application | Cell Biology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 274, 17813-17819 (1999). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
Depositor | Shunsuke Ishii (RIKEN) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |