Strain Data Sheet

RBRC01045

Strain Information

Image
BRC No.RBRC01045
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Mybl2<tm1Sis>/Rbrc
Former Common nameB-Myb Knockout mice
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain descriptionホモは胚盤胞でのICM形成ができないため、致死となる。
Colony maintenanceホモは胚盤胞でのICM形成ができないため、致死となる。ヘテロで維持。
References
B-myb is required for inner cell mass formation at an early stage of development.
Tanaka Y, Patestos N P, Maekawa T, Ishii S
J. Biol. Chem., 274, 28067-28070 (1999). 10497154

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Mybl2
MGI:101785		myeloblastosis oncogene-like 22Mybl2<tm1Sis>
MGI:2445746		targeted mutation 1, Shunsuke Ishii
neo neomycin resistance gene (E. coli)2

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal inner cell mass morphology (MP:0002718)

  • embryonic lethality between implantation and somite formation, complete penetrance (MP:0011096)
    • Detailed phenotype data

    Ordering Information

    供与核酸E. coli neo, mouse myeloblastosis oncogene-like2 genomic DNA
    Research applicationCell Biology Research
    提供条件研究成果の公表にあたって譲渡者の指定する文献を引用する。J. Biol. Chem., 274, 28067-28070 (1999).研究成果の公表にあたって謝辞の表明を必要とする。
    Depositor石井　俊輔（独立行政法人理化学研究所）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data