Strain Information | |
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Image | |
BRC No. | RBRC00997 |
Type | Transgene Congenic |
Species | Mus musculus |
Strain name | C57BL/6-TgN(muAqp0)2Tohm |
Former Common name | Tg2, C57BL/6-TgN(muAqp0)2Tohm |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6NCrSlc |
Appearance | black |
Strain development | Developed by Tadashi Okamura, Tohoku University Graduate School of Medicine in 2000. |
Strain description | These transgenic mice expressing Mip in the crystalline lens. These mice exhibit congenital cataracts. However, the cataracts are difficult to detect based on appearance alone. This strain may be useful for studying the onset of cataracts. |
Colony maintenance | |
References | Bilateral congenital cataracts result from a gain-of-function mutation in the gene for aquaporin-0 in mice. Okamura T, Miyoshi I, Takahashi K, Mototani Y, Ishigaki S, Kon Y, Kasai N Genomics, 81, 361-368 (2003). 12676560 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Mip | major intrinsic protein of eye lens fiber | UN | Mip | chicken beta-B1 crystallin promoter, SV40 polyadenylation signal |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | chicken beta-B1 crystallin (Crybb1) promoter, mouse Aquaporin-0 cDNA, SV40 polyadenylation signal |
Research application | |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genomics, 81, 361-368 (2003). |
Depositor | Tadashi Okamura (Tohoku University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |