Strain Data Sheet

RBRC00983

Strain Information

Image
BRC No.RBRC00983
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Gata2<tm1Mym>/Rbrc
Former Common nameGATA-2 2nd Exon GFP knock in
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strainC57BL/6J
Appearanceblack [a/a B/B C/C]
Strain developmentE14ES (129Sv) 由来で、C57BL/6Jと交配。
Strain descriptionGFPの発現を指標にして、GATA-2発現細胞を同定できる。
Colony maintenanceホモノックインマウスは胎生致死(〜11.0)だが、ヘテロマウスは正常で繁殖に問題はない。
References
Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic precursor cells in midgestation mouse embryos.
Naoko Minegishi, Norio Suzuki, Tomomasa Yokomizo, Xiaoqing Pan, Tetsuhiro Fujimoto, Satoru Takahashi, Takahiko Hara, Atsushi Miyajima, Shin-Ichi Nishikawa, Masayuki Yamamoto
Blood, 102, 896-905 (2003). 12689939

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
GFP Green Fluorescent Protein (Aequorea victoria)6
Gata2
MGI:95662		GATA binding protein 26Gata2<tm1Mym>
MGI:2673268		targeted mutation 1, Masayuki Yamamoto
  • acute myeloid leukemia(DisGeNET, MedGEN)

  • deafness-lymphedema-leukemia syndrome(MedGEN)

  • monocytopenia with susceptibility to infections(DisGeNET, MedGEN)
    • more 1 Diseases
  • myelodysplastic syndrome(DisGeNET, MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal blood cell morphology/development (MP:0002429)

  • abnormal definitive hematopoiesis (MP:0002123)

  • embryonic lethality during organogenesis, complete penetrance (MP:0011098)
    • Detailed phenotype data

    Ordering Information

    供与核酸Jellyfish GFP cDNA, mouse GATA-2 genomic DNA
    Research applicationFluorescent Proteins/lacZ System
    提供条件利用者は事前に寄託者の提供承諾書を得る。研究成果の公表にあたって謝辞の表明を必要とする。寄託後2年間は共著を必要とする共同研究とする。当該リソースを使用した研究成果に基づき特許等の申請を行う場合は、寄託者と別途協議を行う。
    Depositor山本　雅之（国立大学法人筑波大学）
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data