Strain Data Sheet

RBRC00951

Strain Information

Image
BRC No.RBRC00951
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Psen1<tm1Shs>/Shs
Former Common namePsen1 null
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Takuji Sirasawa, Tokyo Metropolitan Institute of Gerontology at 2002. A tk-neo cassette from pMC1-neo was inserted into the exon 9 of the Psen1 gene.
Strain descriptionB6.Cg-Psen1<tm1Shs>. Presenilin 1 has been found as a major causal gene for early-onset familial Alzheimer's disease (FAD), involving in the control of the cell cycle in neuronal precursor cells during development. Homozygous mutant embryos exhibit small body size and intracranial hemorrhages at late gestation.
Colony maintenanceBackcross to C57BL/6 (Heterozygote x C57BL/6JJcl)
ReferencesJ. Neurosci. Res., 70(3):501-13 (2002). 12391611
Development, 128, 1391-1402 (2001). 11262239

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Psen1presenilin 112Psen1<tm1Shs>targeted mutation 1, Takuji ShirasawaAd3h, presenilin-1, PS-1, PS1, S182

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)12neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Ordering Information

供与核酸herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse presenilin 1 genomic DNA
Research application
提供条件条件を付加する。利用者は事前に寄託者の提供承諾書を得る。
研究成果の公表にあたって寄託者の指定する文献を引用する。Koizumi et al, Development, 128, 1391-1402 (2001).
利用者は寄託者と共同研究を行う。ただし、共著を必要とする共同研究は寄託後２年間に限定する。
利用者が当該リソースと使用した研究成果に基づく特許等の申請を行う場合は寄託者と別途協議を行う。
Depositor白澤　卓二（(財)東京都高齢者研究福祉振興財団）
Strain Status凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
凍結精子を1ヶ月以内に提供可能
凍結胚を1ヶ月以内に提供可能
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP (Japanese), Lab HP (English)
Genotyping protocol -PCR-

BRC mice in Publications

No Data