Strain Information | |
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Image | |
BRC No. | RBRC00903 |
Type | Targeted Mutation Congenic |
Species | Mus musculus |
Strain name | C.129S2-Pdcd1<tm1Hon>/HonRbrc (N10) |
Former Common name | PD-1-KO-N10 (BALB/c) |
H-2 Haplotype | |
ES Cell line | D3 [129S2/SvPas] |
Background strain | BALB/c |
Appearance | albino [A/A b/b c/c] |
Strain development | Developed by Dr. Tasuku Honjo, Kyoto University |
Strain description | The PD1 (programmed cell death 1) gene is an immunoinhibitory receptor that belongs to the CD28 family, and plays a role in the negative control of proliferation, differentiation and class switching of B cells. Homozygous mutant mice exhibit abnormalities in leukopoiesis and immune system which vary considerably depending on the genetic background. The homozygous mutant mice with BALB/c background exhibit autoimmune dilated cardiomyopathy. The mutant mice of the BALB/c-PD1 (N10 line) show severe dilated cardiomyopathy and start to die as early as 5 weeks of age. Meanwhile, the BALB/c-PD1 (N12) line mutant mice exhibit less severe dilated cardiomyopathy and survive longer than N10 line. |
Colony maintenance | Sibling Mating (Homozygote x Homozygote) Homozygous mutant mice are fertile and viable. |
References | Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Nishimura H, Nose M, Hiai H, Minato N, Honjo T Immunity, 11, 141-151 (1999). 10485649Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Nishimura H, Minato N, Nakano T, Honjo T Int. Immunol., 10, 1563-1572 (1998). 9796923Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Nishimura H, Okazaki T, Tanaka Y, Nakatani K, Hara M, Matsumori A, Sasayama S, Mizoguchi A, Hiai H, Minato N, Honjo T Science, 291, 319-322 (2001). 11209085 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Pdcd1 | programmed cell death 1 | 1 | Pdcd1 | targeted mutation 1, Tasuku Honjo | |||
neo | neomycin resistance gene (E. coli) | 1 | mouse phosphoglycerate kinase promoter (PGK promoter) |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 28 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse PD-1(immunoglobulin superfamily member) genomic DNA |
Research application | Immunology and Inflammation Research |
Specific Term and Conditions | 1) The RECIPIENT shall use the BIOLOGICAL RESOURCE only for academic research for the purpose of publishing the research results. 2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR are requested. Science 291, 319-322 (2001). 3) RECIPIENT shall notify the PROVIDER upon filing a patent application claiming modification of the BIOLOGICAL RESOURCE or method(s) of manufacture or use(s) of the BIOLOGICAL RESOURCE. |
Depositor | Tasuku Honjo (Kyoto University) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- Mouse of the Month Mar 2005 |
BRC mice in Publications |
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No Data |