Strain Data Sheet

RBRC00898

Strain Information

Image
BRC No.RBRC00898
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Aicda<tm1Hon>/HonRbrc
Former Common nameAID-KO (C57BL/6 X CBA) C57BL/6; AID mixed background
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development常法にて遺伝子破壊マウスを作る。Genetic backgroundは(C57BL/6 x CBA) x C57BL/6を使用。2世代目。Cell, 102, 553-563 (2000).参照
Strain description軽度の液性免疫不全がある。IgG, IgA, IgEを産生しない。
Colony maintenanceSPFであれば、特に飼育、交配は、通常通り可能。
References
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.
Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T
Cell, 102, 553-563 (2000). 11007474

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Aicdaactivation-induced cytidine deaminase6Aicdatargeted mutation 1, Tasuku Honjo
  • hyper-IgM syndrome type 2(MedGEN)
    • loxPphage P1 loxP6loxP
  • hyper-IgM syndrome type 2(MedGEN)
    • loxPphage P1 loxP6loxP
  • hyper-IgM syndrome type 2(MedGEN)
    • neoneomycin resistance gene (E. coli)6mouse phosphoglycerate kinase promoter (PGK promoter)
  • hyper-IgM syndrome type 2(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal B cell physiology(MP:0002459)

  • abnormal class switch recombination(MP:0004816)

  • abnormal immunoglobulin heavy chain V(D)J recombination(MP:0008760)

  • abnormal somatic hypermutation frequency(MP:0004815)

  • decreased IgA level(MP:0001807)
    • more 9 phenotypes
  • decreased IgG level(MP:0001805)

  • decreased IgG1 level(MP:0008495)

  • decreased IgG2a level(MP:0008496)

  • decreased IgG2b level(MP:0008497)

  • decreased IgG3 level(MP:0008498)

  • immune system phenotype(MP:0005387)

  • increased IgM level(MP:0002494)

  • increased germinal center B cell number(MP:0008177)

  • increased susceptibility to bacterial infection induced morbidity/mortality(MP:0009788)
    • Detailed phenotype data

    Ordering Information

    供与核酸Phage P1 loxP sites, E. coli Neomycin resistance gene, Mouse Phosphoglycerate kinase promoter (PGK promoter), mouse Aicda genomic DNA
    Research applicationCre/loxP system
    Immunology and Inflammation Research
    提供条件条件を付加する。
    1. 公表を前提とした学術研究に限る。
    2. 研究成果の公表にあたって寄託者への謝辞の表明並びに寄託者の指定する文献を引用する。Cell 102, 553-563 (2000).
    3. 本件リソースの改変体又は本件リソースの生産方法若しくは使用方法に係る特許を出願した場合、その旨を速やかに寄託者に通知する。
    Depositor本庶　佑（京都大学）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability受注後、検査を施して提供
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Honjo Lab HP

    BRC mice in Publications

    No Data