Strain Data Sheet

RBRC00898

Strain Information

Image
BRC No.RBRC00898
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Aicda<tm1Hon>/HonRbrc
Former Common nameAID-KO (C57BL/6 X CBA) C57BL/6; AID mixed background
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.
Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T
Cell, 102, 553-563 (2000). 11007474

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Aicdaactivation-induced cytidine deaminase6Aicdatargeted mutation 1, Tasuku Honjo
  • hyper-IgM syndrome type 2(MedGEN)
    • loxPphage P1 loxP6loxP
  • hyper-IgM syndrome type 2(MedGEN)
    • loxPphage P1 loxP6loxP
  • hyper-IgM syndrome type 2(MedGEN)
    • neoneomycin resistance gene (E. coli)6mouse phosphoglycerate kinase promoter (PGK promoter)
  • hyper-IgM syndrome type 2(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal B cell physiology(MP:0002459)

  • abnormal class switch recombination(MP:0004816)

  • abnormal immunoglobulin heavy chain V(D)J recombination(MP:0008760)

  • abnormal somatic hypermutation frequency(MP:0004815)

  • decreased IgA level(MP:0001807)
    • more 9 phenotypes
  • decreased IgG level(MP:0001805)

  • decreased IgG1 level(MP:0008495)

  • decreased IgG2a level(MP:0008496)

  • decreased IgG2b level(MP:0008497)

  • decreased IgG3 level(MP:0008498)

  • immune system phenotype(MP:0005387)

  • increased IgM level(MP:0002494)

  • increased germinal center B cell number(MP:0008177)

  • increased susceptibility to bacterial infection induced morbidity/mortality(MP:0009788)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP sites, E. coli Neomycin resistance gene, Mouse Phosphoglycerate kinase promoter (PGK promoter), mouse Aicda genomic DNA
    Research applicationCre/loxP system
    Immunology and Inflammation Research
    Specific Term and Conditions1) The RECIPIENT shall use the BIOLOGICAL RESOURCE only for academic research for the purpose of publishing the research results.
    2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR are requested. Cell 102, 553-563 (2000).
    3) RECIPIENT shall notify the PROVIDER upon filing a patent application claiming modification of the BIOLOGICAL RESOURCE or method(s) of manufacture or use(s) of the BIOLOGICAL RESOURCE.
    DepositorTasuku Honjo (Kyoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Honjo Lab HP

    BRC mice in Publications

    No Data