Strain Data Sheet

RBRC00897

Strain Information

Image
BRC No.RBRC00897
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Aicda<tm1Hon> (N10)/HonRbrc
Former Common nameAID-KO C57BL/6 N10, B6-AID KO#N10, B6.Cg-Aicda<tm1Hon> (N10)/HonRbrc
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
AppearanceBlack [a/a B/B C/C]
Strain development常法にて遺伝子破壊マウスを作る。Genetic backgroundは(C57BL/6 x CBA) x C57BL/6を親として、これに10回C57BL/6へ戻し交配した。Cell, 102, 553-563 (2000).参照
Strain description軽度の液性免疫不全がある。IgG, IgA, IgEを産生しない。
Colony maintenanceSPFであれば、特に飼育、交配は、通常通り可能。
ReferencesCell, 102, 553-563 (2000). 11007474

Health Report

Examination Date / Room / Rack2024/01/09Room:3-ARack:I
2023/10/10Room:3-ARack:I
2023/07/10Room:3-ARack:I
2023/04/10Room:3-ARack:I
2023/01/10Room:3-ARack:I
2022/10/11Room:3-ARack:I
2022/07/11Room:3-ARack:I

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Aicdaactivation-induced cytidine deaminase6Aicda<tm1Hon>targeted mutation 1, Tasuku HonjoAID

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP6loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP6loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)6neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter)

Ordering Information

供与核酸phage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Activation-induced cytidine deaminase (AID) genomic DNA
Research applicationCre/loxP system
Immunology and Inflammation Research
提供条件条件を付加する。
1. 公表を前提とした学術研究に限る。
2. 研究成果の公表にあたって寄託者への謝辞の表明並びに寄託者の指定する文献を引用する。Cell 102, 553-563 (2000).
3. 本件リソースの改変体又は本件リソースの生産方法若しくは使用方法に係る特許を出願した場合、その旨を速やかに寄託者に通知する。
Depositor本庶　佑（京都大学）
Strain Status生体のアイコン生体
凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結精子を1ヶ月以内に提供可能
凍結胚を1ヶ月以内に提供可能
生体マウスを1~3ヶ月以内に提供可能
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)
Honjo Lab HP
Genotyping protocol -PCR-
Genetic Background
Mouse of the Month Dec 2005

BRC mice in Publications

Matsumoto M, Sasaki Y, Yasuda K, Takai T, Muramatsu M, Yoshimoto T, Nakanishi K.
IgG and IgE collaboratively accelerate expulsion of Strongyloides venezuelensis in a primary infection.
Infect Immun 81(7) 2518-27(2013) 23630966

Bello A, Müller A, Hirth G, Giebeler LN, Böttcher K, Voigt S, Jungnickel B.
Cell Cycle-Mediated Regulation of Secondary Ig Diversification.
J Immunol 210(10) 1508-1518(2023) 37000470

Kato M, Tsuji-Kawahara S, Kawasaki Y, Kinoshita S, Chikaishi T, Takamura S, Fujisawa M, Kawada A, Miyazawa M.
Class switch recombination and somatic hypermutation of virus-neutralizing antibodies are not essential for control of friend retrovirus infection.
J Virol 89(2) 1468-73(2015) 25378499

Luo Y, Zhang X, Chen R, Li R, Liu Y, Zhang J, Liu Q, Si M, Liu J, Wu B, Wang X, Wu S, Zhang Y, Zhang X, Guo D, He X, Pan T, Zhang H.
USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID.
Signal Transduct Target Ther 7(1) 7(2022) 34983926