Strain Data Sheet

RBRC00896

Strain Information

Image
BRC No.RBRC00896
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6-Tg(CAG-Aicda,CAG-EGFP)C1Hon/HonRbrc
Former Common nameAID-Tg line #C1
H-2 Haplotype
ES Cell line
Background strainC57BL/6NCrSlc
Appearance
Strain development開発年：2002年開発者：本庶佑先生、岡崎一美先生機関名：京都大学大学院医学研究科・分子生物学
Strain descriptionmAIDを全身で恒常的に発現する。
Colony maintenance
References
Constitutive expression of AID leads to tumorigenesis.
Okazaki I M, Hiai H, Kakazu N, Yamada S, Muramatsu M, Kinoshita K, Honjo T
J. Exp. Med., 197, 1173-1181 (2003). 12732658

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Aicdaactivation-induced cytidine deaminaseUNAicdaCAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
  • hyper-IgM syndrome type 2(MedGEN)
    • GFPGreen Fluorescent Protein (Aequorea victoria)UNCAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
  • hyper-IgM syndrome type 2(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal gut flora balance(MP:0010377)

  • abnormal lung adenoma incidence(MP:0020190)

  • abnormal lymphopoiesis(MP:0002401)

  • abnormal thymus size(MP:0002364)

  • decreased CD4-positive, alpha-beta T cell number(MP:0008075)
    • more 12 phenotypes
  • decreased CD8-positive, alpha-beta T cell number(MP:0008079)

  • decreased birth body size(MP:0009703)

  • enlarged lymph nodes(MP:0000702)

  • enlarged spleen(MP:0000691)

  • epidermal cyst(MP:0003414)

  • immune system phenotype(MP:0005387)

  • increased lung adenocarcinoma incidence(MP:0002027)

  • increased lymphoma incidence(MP:0012431)

  • increased susceptibility to bacterial infection induced morbidity/mortality(MP:0009788)

  • increased susceptibility to bacterial infection(MP:0002412)

  • large lymphoid organs(MP:0002220)

  • small thymus(MP:0000706)
    • Detailed phenotype data

    Ordering Information

    供与核酸CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA), mouse Aicda cDNA, Jellyfish GFP cDNA
    Research applicationCancer Research
    Fluorescent Proteins/lacZ System
    Immunology and Inflammation Research
    提供条件1. 公表を前提とした学術研究に限る。
    2. 研究成果の公表にあたって寄託者への謝辞の表明並びに寄託者の指定する文献を引用する。J. Exp. Med., 197, 1173-1181 (2003).
    3. 本件リソースの改変体又は本件リソースの生産方法若しくは使用方法に係る特許を出願した場合、その旨を速やかに寄託者に通知する。
    Depositor本庶　佑（京都大学）
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. CAGGS MTA (English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Honjo Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data