Strain Data Sheet

RBRC00889

Strain Information

Image
BRC No.RBRC00889
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameSTOCK Spen<tm1Hon>/HonRbrc
Former Common nameMINT-KO (ICR background)
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strainSlc:ICR
Appearancealbino
Strain development
Strain description
Colony maintenance
References
Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway.
Kuroda K, Han H, Tani S, Tanigaki K, Tun T, Furukawa T, Taniguchi Y, Kurooka H, Hamada Y, Toyokuni S, Honjo T
Immunity, 18, 301-312 (2003). 12594956

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Spenspen family transcription repressor4Spentargeted mutation 1, Tasuku Honjo
neoneomycin resistance gene (E. coli)4mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal B cell differentiation(MP:0002144)

  • abnormal heart development(MP:0000267)

  • abnormal pancreas development(MP:0003934)

  • lethality throughout fetal growth and development, complete penetrance(MP:0011099)

  • liver hypoplasia(MP:0000600)
  • more 2 phenotypes
  • small liver(MP:0000601)

  • translucent skin(MP:0001201)
  • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Spen genomic DNA
    Research applicationDevelopmental Biology Research
    Immunology and Inflammation Research
    Internal/Organ Research
    Specific Term and Conditions1) The RECIPIENT shall use the BIOLOGICAL RESOURCE only for academic research for the purpose of publishing the research results.
    2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR are requested. Immunity 18, 301-312 (2003).
    3) RECIPIENT shall notify the PROVIDER upon filing a patent application claiming modification of the BIOLOGICAL RESOURCE or method(s) of manufacture or use(s) of the BIOLOGICAL RESOURCE.
    DepositorTasuku Honjo (Kyoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Honjo Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data