Strain Data Sheet

RBRC00887

Strain Information

Image
BRC No.RBRC00887
TypeCongenic
SpeciesMus musculus
Strain nameNFS.SL-Bomb1<SL/Kh>
Former Common nameNFS-Bomb1 congenic, NFS-Bomb1<SL/SL>
H-2 Haplotype
ES Cell line
Background strain
Appearancealbino [c/c]
Strain development2002年、congenic Line 作出、日合弘先生、京都大学病態生物医学（NFS×SL/Kh)をNFSに12世代戻し交配後、兄妹交配。
Strain descriptionNFS系にSL/Kh Bomb1 alleleを導入。FACSにてBP1+B220+DP cellsの異常増殖を確認。リンパ腫の自然発生なし。
Colony maintenance近交系として維持。NFSが背景にあるので繁殖は良好。
References
Abnormal bone marrow B-cell differentiation in pre-B lymphoma-prone SL/Kh mice.
K Okamoto, Y Yamada, M S Ogawa, S Toyokuni, Y Nakakuki, H Ikeda, O Yoshida, H Hiai
Cancer Res., 54, 399-402 (1994). 8275475

Bone marrow pre-B-1 (Bomb1): a quantitative trait locus inducing bone marrow pre-B-cell expansion in lymphoma-prone SL/Kh mice.
L M Lu, R Shimada, S Higashi, Z Zeng, H Hiai
Cancer Res., 59, 2593-2595 (1999). 10363979

Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis.
Takuya Hiratsuka, Tatsuaki Tsuruyama, Richard Kaszynski, Kohei Kometani, Nagahiro Minato, Takuro Nakamura, Keiji Tamaki, Hiroshi Hiai
Leuk. Res., 32,　309-314　(2008). 17617450

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Bomb1
MGI:1332642		bone marrow pre-B 13Bomb1<SL/Kh>
MGI:2155342

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • increased lymphoma incidence (MP:0012431)

  • increased pre-B cell number (MP:0003132)
    • Detailed phenotype data

    Ordering Information

    供与核酸
    Research applicationCancer Research
    提供条件NFS-Bomb1SL/SLcongenic miceについては供与者の研究室から第一報の論文が出版された後に、一般の利用と供するものとする。
    Depositor日合　弘（京都大学）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data