Strain Data Sheet

RBRC00887

Strain Information

Image
BRC No.RBRC00887
TypeCongenic
SpeciesMus musculus
Strain nameNFS.SL-Bomb1<SL/Kh>
Former Common nameNFS-Bomb1 congenic, NFS-Bomb1<SL/SL>
H-2 Haplotype
ES Cell line
Background strain
Appearancealbino [c/c]
Strain developmentDeveloped by Dr. Hiroshi Hiai, Kyoto University Graduate School of Medicine in 2002. This congenic strain was produced by backcrossing SL/Kh to NFS/N for 12 times.
Strain descriptionThis congenic strain carries Bomb1 (bone marrow pre-B1) loci on Chr3 introduced by backcrossing from NFS/N to SL/Kh, and shows an abnormal transient expansion of bone marrow pre-B cell.
Colony maintenanceSibling Mating (Homozygote x Homozygote)
References
Abnormal bone marrow B-cell differentiation in pre-B lymphoma-prone SL/Kh mice.
K Okamoto, Y Yamada, M S Ogawa, S Toyokuni, Y Nakakuki, H Ikeda, O Yoshida, H Hiai
Cancer Res., 54, 399-402 (1994). 8275475

Bone marrow pre-B-1 (Bomb1): a quantitative trait locus inducing bone marrow pre-B-cell expansion in lymphoma-prone SL/Kh mice.
L M Lu, R Shimada, S Higashi, Z Zeng, H Hiai
Cancer Res., 59, 2593-2595 (1999). 10363979

Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis.
Takuya Hiratsuka, Tatsuaki Tsuruyama, Richard Kaszynski, Kohei Kometani, Nagahiro Minato, Takuro Nakamura, Keiji Tamaki, Hiroshi Hiai
Leuk. Res., 32,　309-314　(2008). 17617450

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Bomb1
MGI:1332642		bone marrow pre-B 13Bomb1<SL/Kh>
MGI:2155342

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • increased lymphoma incidence (MP:0012431)

  • increased pre-B cell number (MP:0003132)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationCancer Research
    Specific Term and Conditions
    DepositorHiroshi Hiai (Kyoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data