Strain Data Sheet

RBRC00855

update : 2026-07-17

Strain Information
Image
BRC No.	RBRC00855
Type	Major Histocompatibility Complex (H2) Congenic
Species	Mus musculus
Strain name	NZW.PL(H2<u>)
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References	Dissection of the effects of tumor necrosis factor-alpha and class II gene polymorphisms within the MHC on murine systemic lupus erythematosus (SLE). T Fujimura, S Hirose, Y Jiang, S Kodera, H Ohmuro, D Zhang, Y Hamano, H Ishida, S Furukawa, T Shirai Int. Immunol., 10, 1467-1472 (1998). 9796913

Health Report
Examination Date / Room / Rack

Gene
Gene Symbol	Gene Name	Chr.	Allele Symbol	Allele Name	Common Names	Promoter	Diseases Related to This Gene
H2 MGI:95894	histocompatibility-2, MHC	17	H2<u> MGI:3834991	u variant

Phenotype
Phenotype annotation from literatures by Mammalian phenotype ontology	abnormal CD4-positive, alpha-beta T cell physiology (MP:0005463) abnormal double-negative T cell morphology (MP:0002407) abnormal double-positive T cell morphology (MP:0002408) abnormal effector T cell morphology (MP:0002435) abnormal thymus cell ratio (MP:0008827) more 11 phenotypes absent gamma-delta T cells (MP:0008348) decreased CD4-positive, alpha-beta T cell number (MP:0008075) decreased CD8-positive, alpha-beta T cell number (MP:0008079) decreased double-positive T cell number (MP:0005092) decreased thymocyte number (MP:0000715) increased CD4-positive, alpha-beta T cell number (MP:0008074) increased T cell derived lymphoma incidence (MP:0002024) increased autoantibody level (MP:0003725) increased double-negative T cell number (MP:0005090) increased susceptibility to experimental autoimmune encephalomyelitis (MP:0004799) paralysis (MP:0000753)
Detailed phenotype data

Phenotype annotation from literatures by Mammalian phenotype ontology

abnormal CD4-positive, alpha-beta T cell physiology (MP:0005463)

abnormal double-negative T cell morphology (MP:0002407)

abnormal double-positive T cell morphology (MP:0002408)

abnormal effector T cell morphology (MP:0002435)

abnormal thymus cell ratio (MP:0008827)

more 11 phenotypes

absent gamma-delta T cells (MP:0008348)

decreased CD4-positive, alpha-beta T cell number (MP:0008075)

decreased CD8-positive, alpha-beta T cell number (MP:0008079)

decreased double-positive T cell number (MP:0005092)

decreased thymocyte number (MP:0000715)

increased CD4-positive, alpha-beta T cell number (MP:0008074)

increased T cell derived lymphoma incidence (MP:0002024)

increased autoantibody level (MP:0003725)

increased double-negative T cell number (MP:0005090)

increased susceptibility to experimental autoimmune encephalomyelitis (MP:0004799)

paralysis (MP:0000753)

Detailed phenotype data

Ordering Information
Donor DNA
Research application	Immunology and Inflammation Research
Specific Term and Conditions	In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Int Immunol., 10, 1467-1472 (1998).
Depositor	Sachiko Hirose (Juntendo University)
Strain Status	Frozen embryos
Strain Availability	Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month)
Additional Info.	Necessary documents for ordering: Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

BRC mice in Publications

No Data