Strain Data Sheet

RBRC00855

update : 2025-08-20

Strain Information
Image
BRC No.	RBRC00855
Type	Major Histocompatibility Complex (H2) Congenic
Species	Mus musculus
Strain name	NZW.PL(H2<u>)
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References	Dissection of the effects of tumor necrosis factor-alpha and class II gene polymorphisms within the MHC on murine systemic lupus erythematosus (SLE). Fujimura T, Hirose S, Jiang Y, Kodera S, Ohmuro H, Zhang D, Hamano Y, Ishida H, Furukawa S, Shirai T Int. Immunol., 10, 1467-1472 (1998). 9796913

Health Report
Examination Date / Room / Rack

Gene
Gene Symbol	Gene Name	Chr.	Allele Symbol	Allele Name	Common Names	Promoter	Diseases Related to This Gene
H2 MGI:95894	histocompatibility-2, MHC	17	H2<u> MGI:3834991	u variant

Phenotype
Phenotype annotation from literatures by Mammalian phenotype ontology	abnormal CD4-positive, alpha-beta T cell physiology (MP:0005463) abnormal double-negative T cell morphology (MP:0002407) abnormal double-positive T cell morphology (MP:0002408) abnormal effector T cell morphology (MP:0002435) abnormal thymus cell ratio (MP:0008827) more 11 phenotypes absent gamma-delta T cells (MP:0008348) decreased CD4-positive, alpha-beta T cell number (MP:0008075) decreased CD8-positive, alpha-beta T cell number (MP:0008079) decreased double-positive T cell number (MP:0005092) decreased thymocyte number (MP:0000715) increased CD4-positive, alpha-beta T cell number (MP:0008074) increased T cell derived lymphoma incidence (MP:0002024) increased autoantibody level (MP:0003725) increased double-negative T cell number (MP:0005090) increased susceptibility to experimental autoimmune encephalomyelitis (MP:0004799) paralysis (MP:0000753)
Detailed phenotype data

Phenotype annotation from literatures by Mammalian phenotype ontology

abnormal CD4-positive, alpha-beta T cell physiology (MP:0005463)

abnormal double-negative T cell morphology (MP:0002407)

abnormal double-positive T cell morphology (MP:0002408)

abnormal effector T cell morphology (MP:0002435)

abnormal thymus cell ratio (MP:0008827)

more 11 phenotypes

absent gamma-delta T cells (MP:0008348)

decreased CD4-positive, alpha-beta T cell number (MP:0008075)

decreased CD8-positive, alpha-beta T cell number (MP:0008079)

decreased double-positive T cell number (MP:0005092)

decreased thymocyte number (MP:0000715)

increased CD4-positive, alpha-beta T cell number (MP:0008074)

increased T cell derived lymphoma incidence (MP:0002024)

increased autoantibody level (MP:0003725)

increased double-negative T cell number (MP:0005090)

increased susceptibility to experimental autoimmune encephalomyelitis (MP:0004799)

paralysis (MP:0000753)

Detailed phenotype data

Ordering Information
Donor DNA
Research application	Immunology and Inflammation Research
Specific Term and Conditions	In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Int Immunol., 10, 1467-1472 (1998).
Depositor	Sachiko Hirose (Juntendo University)
Strain Status	Frozen embryos
Strain Availability	Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month)
Additional Info.	Necessary documents for ordering: Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

BRC mice in Publications

No Data