Strain Data Sheet

RBRC00849

Strain Information

Image
BRC No.RBRC00849
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameB6;KOR1-Traf3ip2<adjm>
Former Common nameB6.NAD
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearanceblack
Strain developmentDeveloped by Dr. Yoshibumi Matsushima, Research Institute for Clinical Oncology, Saitama Cancer Center.
Strain descriptionC57BL/6 congenic strain having a sponatenous mutation found in a colony of the KOR inbred strain derived from Japanese wild mice. Homozygous mutant mice show high levels of serum IgE and an atopic dermatitis (AD)-like skin disease. The pehotype of this strain is less than on the KOR orinigal strain. Homozygous mutant mice are viable and fertile.
Colony maintenance
References
An atopic dermatitis-like skin disease with hyper-IgE-emia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2 (Act1/CIKS) gene.
Matsushima Y, Kikkawa Y, Takada T, Matsuoka K, Seki Y, Yoshida H, Minegishi Y, Karasuyama H, Yonekawa H
J. Immunol., 185, 2340-2349 (2010). 20660351

Japanese wild mice: a rich resource for new disease models.
Matsushima Y
Exp. Anim., 61, 25-33 (2012). 22293669

Characteristics of scratching behavior in ADJM mice (atopic dermatitis from Japanese mice).
Nakasone T, Sato T, Matsushima Y, Inoue T, Kamei C
Immunopharmacol Immunotoxicol, 37, 202-206 (2015). 25578901

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Traf3ip2
MGI:2143599		TRAF3 interacting protein 210Traf3ip2<adjm>
MGI:4820827		atopic dermatitis from Japanese mice
  • candidiasis, familial, 8(MedGEN)

  • psoriasis 13, susceptibility to(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • dermatitis(MP:0001194)

  • female infertility(MP:0001926)

  • increased IgE level(MP:0002497)

  • increased pruritus(MP:0010072)

  • premature death(MP:0002083)
    • more 1 phenotypes
  • thick epidermis(MP:0001219)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDermatology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunol., 185, 2340-2349 (2010). Immunopharmacol Immunotoxicol, 37, 202-206 (2015).
    DepositorYoshibumi Matsushima (Saitama Cancer Center)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data