Strain Data Sheet

RBRC00824

Strain Information

Image
BRC No.RBRC00824
TypeChromosomal Aberration
SpeciesMus musculus
Strain nameSTOCK T(X;16)16H +/+ Eda<Ta>/Rbrc
Former Common nameSearle, T(X;16)16H
H-2 Haplotype
ES Cell line
Background strain
AppearanceTabby [XY]
wild [T16H/+]
Strain development
Strain description
Colony maintenance
References
Reversal of X-inactivation in female mouse somatic cells hybridized with murine teratocarcinoma stem cells in vitro.
Takagi N, Yoshida M A, Sugawara O, Sasaki M
Cell, 34, 1053-1062 (1983). 6627391

Cytogenetics of the Mammalian X Chromosome, Part A Basic Mechanisms of X Chromosome Behavior, 21-50 (1983).

Detrimental effects of two active X chromosomes on early mouse development.
Takagi N, Abe K
Development, 109, 189-201 (1990). 2209464

Translocation breakpoint possibly predisposes to nonrandom X-chromosome inactivation in mouse embryos bearing Searle's T(X;16)16H translocation.
Ogura H, Takada S, Mise N, Sugimoto M, Tan S S, Takagi N
Cytogenet. Cell Genet., 80, 173-178 (1998). 9678353

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
T(X;16)16H
MGI:104279		reciprocal translocation, Chr X and 16, Harwell 1616T(X;16)16H
MGI:3032980
Eda
MGI:1195272		ectodysplasin-AXEda<Ta> tabby
  • tooth agenesis, selective, X-linked, 1(MedGEN)

  • X-linked hypohidrotic ectodermal dysplasia(MedGEN)
    • T(X;16)16H
    MGI:104278    		reciprocal translocation, Chr X and 16, Harwell 16XT(X;16)16H
    MGI:3032981

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal autopod morphology(MP:0000572)

  • abnormal coat appearance(MP:0001510)

  • abnormal coat/ hair morphology(MP:0000367)

  • abnormal coat/hair pigmentation(MP:0002075)

  • abnormal enamel morphology(MP:0002576)
    • more 40 phenotypes
  • abnormal eye morphology(MP:0002092)

  • abnormal eyelid morphology(MP:0001340)

  • abnormal guard hair morphology(MP:0000397)

  • abnormal hair follicle development(MP:0003704)

  • abnormal hair follicle melanocyte morphology(MP:0004381)

  • abnormal hair follicle pheomelanosome pheomelanin content(MP:0006370)

  • abnormal hair growth(MP:0002073)

  • abnormal hair texture(MP:0002074)

  • abnormal incisor morphology(MP:0005358)

  • abnormal lateral nasal gland morphology(MP:0013582)

  • abnormal molar morphology(MP:0002689)

  • abnormal molar root morphology(MP:0030494)

  • abnormal nasal cavity morphology(MP:0002237)

  • abnormal nasal gland morphology(MP:0013580)

  • abnormal nose morphology(MP:0002233)

  • abnormal palatal rugae morphology(MP:0009652)

  • abnormal respiratory mucosa morphology(MP:0002277)

  • abnormal respiratory system morphology(MP:0002132)

  • abnormal skeleton morphology(MP:0005508)

  • abnormal skin pigmentation(MP:0002095)

  • abnormal tail morphology(MP:0002111)

  • abnormal tail ring morphology(MP:0012078)

  • abnormal tail tip morphology(MP:0013177)

  • abnormal vibrissa number(MP:0009003)

  • absent Meibomian glands(MP:0006236)

  • absent eccrine glands(MP:0000577)

  • absent guard hair(MP:0006365)

  • absent hair follicle pheomelanosome pheomelanin(MP:0006371)

  • absent vibrissae(MP:0001284)

  • absent zigzag hairs(MP:0006366)

  • focal hair loss(MP:0000418)

  • hairless tail(MP:0010233)

  • irregular coat pigmentation(MP:0000372)

  • kinked tail(MP:0000585)

  • narrow eye opening(MP:0005287)

  • short incisors(MP:0004830)

  • striated fur(MP:0009659)

  • thin epidermis(MP:0001218)

  • thin skin(MP:0001199)

  • transverse fur striping(MP:0010231)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDevelopmental Biology Research
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorNobuo Takagi (Hokkaido University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data