Strain Data Sheet

RBRC00816

Strain Information

Image
BRC No.RBRC00816
TypeTargeted Mutation and TransgeneCartagena
SpeciesMus musculus
Strain nameB6;129P2(B6)-Prnp<tm1Ito> Tg(CAG-PRNP)1Ondr/Rbrc
Former Common namescimitar-homed oryx PrP mouse
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Comparative analysis of the prion protein open reading frame nucleotide sequences of two wild ruminants, the moufflon and golden takin.
Seo S W, Hara K, Kubosaki A, Nasu Y, Nishimura T, Saeki K, Matsumoto Y, Endo H, Onodera T
Intervirology, 44, 359-363 (2001). 11805443

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
PrnPprion protein2PrnPtargeted mutation 1, Shigeyoshi Itohara
  • fatal familial insomnia(DisGeNET, MedGEN)

  • Gerstmann-Straussler-Scheinker syndrome(DisGeNET, MedGEN)

  • Huntington disease-like 1(MedGEN)
    • more 3 Diseases
  • inherited Creutzfeldt-Jakob disease(MedGEN)

  • kuru, susceptibility to(MedGEN)

  • spongiform encephalopathy with neuropsychiatric features(MedGEN)
    • neoneomycin resistance gene (E. coli)2mouse phosphoglycerate kinase promoter (PGK promoter)
  • fatal familial insomnia(DisGeNET, MedGEN)

  • Gerstmann-Straussler-Scheinker syndrome(DisGeNET, MedGEN)

  • Huntington disease-like 1(MedGEN)
    • more 3 Diseases
  • inherited Creutzfeldt-Jakob disease(MedGEN)

  • kuru, susceptibility to(MedGEN)

  • spongiform encephalopathy with neuropsychiatric features(MedGEN)
    • PRNPprion protein (Orix)UNPRNPCAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
  • fatal familial insomnia(DisGeNET, MedGEN)

  • Gerstmann-Straussler-Scheinker syndrome(DisGeNET, MedGEN)

  • Huntington disease-like 1(MedGEN)
    • more 3 Diseases
  • inherited Creutzfeldt-Jakob disease(MedGEN)

  • kuru, susceptibility to(MedGEN)

  • spongiform encephalopathy with neuropsychiatric features(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • ataxia(MP:0001393)

  • tremors(MP:0000745)
    • Detailed phenotype data

    Ordering Information

    Donor DNACAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA), scimitar-homed oryx PrP cDNA, E. coli neo, rabbit beta-globin splicer, 3 UTR, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse PrnP genomic DNA
    Research applicationCardiovascular Research
    Mouse Models for Human Disease
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorTakashi Onodera (The University of Tokyo)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. CAGGS MTA (English)
    5. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data