Strain Data Sheet

RBRC00803

Strain Information

Image
BRC No.RBRC00803
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Gfap<tm4Ito>/Rbrc
Former Common nameGfap hm3-KI
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strainC57BL/6JJcl
Appearance
Strain development2002年、竹村　理明、糸原　重美、理化学研究所
Strain description
Colony maintenance繁殖効率：A
References
Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice.
Takemura M, Gomi H, Colucci-Guyon E, Itohara S
J. Neurosci., 22, 6972-6979 (2002). 12177195

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
GFAPglial fibrillary acidic protein (human)11GFAP
  • Alexander disease(DisGeNET, MedGEN)
    • Gfapglial fibrillary acidic protein11Gfaptargeted mutation 4, Shigeyoshi Itohara
  • Alexander disease(DisGeNET, MedGEN)
    • loxPphage P1 loxP11loxP
  • Alexander disease(DisGeNET, MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal CNS glial cell morphology(MP:0000952)

  • abnormal astrocyte morphology(MP:0002182)
    • Detailed phenotype data

    Ordering Information

    供与核酸human GFAP cDNA, Phage P1 loxP site, mouse Gfap genomic DNA
    Research applicationCre/loxP system
    提供条件条件を付加する。
    研究成果の公表にあたって寄託者の指定する文献を引用する。J. Neurosci., 22, 6972-6979 (2002).
    Depositor糸原　重美（理化学研究所脳科学総合研究センター）
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data