Strain Data Sheet

RBRC00803

Strain Information

Image
BRC No.RBRC00803
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Gfap<tm4Ito>/Rbrc
Former Common nameGfap hm3-KI
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strainC57BL/6JJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice.
Takemura M, Gomi H, Colucci-Guyon E, Itohara S
J. Neurosci., 22, 6972-6979 (2002). 12177195

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
GFAP glial fibrillary acidic protein (human)11GFAP
Gfap
MGI:95697		glial fibrillary acidic protein11Gfap<tm4Ito>
MGI:2384721		targeted mutation 4, Shigeyoshi Itohara
  • Alexander disease(DisGeNET, MedGEN)
    • loxP phage P1 loxP11loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal CNS glial cell morphology(MP:0000952)

  • abnormal astrocyte morphology(MP:0002182)
    • Detailed phenotype data

    Ordering Information

    Donor DNAhuman GFAP cDNA, Phage P1 loxP site, mouse Gfap genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci., 22, 6972-6979 (2002).
    DepositorShigeyoshi Itohara (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data