Strain Data Sheet

RBRC00777

Information1

Image
BRC No.RBRC00777
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameFVB/N-Mkrn1-ps1<Tg(Polr3e)>/Rbrc
Former Common nameSex-lethal transgeneic mouse, SL-T,D
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by National Institute of Genome in 1998.
Strain descriptionThis strain, which has multiple bone and kidney defects, arose from transgenic lines in which the Sex-lethal gene of Drosophila had been introduced. The insertional mutagenesis of the Mkrn1-ps gene has been confirmed. The phenotype is only apparent when the mutant allele is transmitted from the male parent. This strain may be useful for studies on the formation of bone and kidney.
Colony maintenance
ReferencesNature, 423, 91-96 (2003). 12721631

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Mkrn1-ps1makorin, ring finger proteion 1, psedogene 15Mkrn1-ps1

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Polr3eDrosophila Sex-lethalUNPolr3ehCMV-1 promoter

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
tTAtTA (E. coli tet repressor (TetR), herpes simplex virus (HSV) VP16 activation domain)UNtTAE. coli tet repressor (TetR), herpes simplex virus (HSV)VP16 activation domainCMV promoter

Information2

Donor DNACMV promoter, E. coli tet repressor (TetR), herpes simplex virus (HSV)VP16 activation domain, Drosophila Sex-lethal cDNA, PhCMV-1 promoter, E. coli Tetracyclin promoter
Research applicationInternal/Organ Research
Tet system
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature, 423, 91-96 (2003).
DepositorShinji Hirotsune (Osaka City University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data