Strain Information | |
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Image | |
BRC No. | RBRC00777 |
Type | Transgene |
Species | Mus musculus |
Strain name | FVB/N-Mkrn1-ps1<Tg(Polr3e)>/Rbrc |
Former Common name | Sex-lethal transgeneic mouse, SL-T,D |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by National Institute of Genome in 1998. |
Strain description | This strain, which has multiple bone and kidney defects, arose from transgenic lines in which the Sex-lethal gene of Drosophila had been introduced. The insertional mutagenesis of the Mkrn1-ps gene has been confirmed. The phenotype is only apparent when the mutant allele is transmitted from the male parent. This strain may be useful for studies on the formation of bone and kidney. |
Colony maintenance | |
References | An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene. Hirotsune S, Yoshida N, Chen A, Garrett L, Sugiyama F, Takahashi S, Yagami K, Wynshaw-Boris A, Yoshiki A Nature, 423, 91-96 (2003). 12721631 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Mkrn1-ps1 | makorin, ring finger protein 1, pseudogene 1 | 5 | Mkrn1-ps1 | ||||
Polr3e | Drosophila Sex-lethal | UN | Polr3e | hCMV-1 promoter | |||
tTA | tTA (E. coli tet repressor (TetR), herpes simplex virus (HSV) VP16 activation domain) | UN | tTA | CMV promoter |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 4 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | CMV promoter, E. coli tet repressor (TetR), herpes simplex virus (HSV)VP16 activation domain, Drosophila Sex-lethal cDNA, PhCMV-1 promoter, E. coli Tetracyclin promoter |
Research application | Internal/Organ Research Tet system |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature, 423, 91-96 (2003). |
Depositor | Shinji Hirotsune (Osaka City University) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |