Strain Data Sheet



BRC No.RBRC00765
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameINAD
Former Common nameinfantile neuroaxonal dystrophy: INAD
H-2 Haplotype
ES Cell line
Background strainC57BL/6
Appearanceblack [(a/a B/B C/C)]
Strain developmentDiscovered in a C57BL/6 breeding colony. Developed by Dr. Yoshibumi Matsushima, Saitama Cancer Center in 2005.
Strain descriptionThe spontaneous mutation that was discovered in a C57BL/6 breeding colony. Homozygous mutant mice exhibit the incoordinated limbs and lean body in the lower half of the body, and die from 4 to 5 weeks after birth. In these mice, a neurodystrophic change appearing as spheroid bodies in central and peripheral nervous system is observed. This strain is useful as a mouse model for infantile neuroaxonal dystrophy (INAD).
Colony maintenanceSibling Mating (Heterozygote x Heterozygote) or Transplant-Cross-Intercross (maintenace by ovary transplantation, Homozygote x Heterozygote)Homozygous mutant mice die before sexual maturity.
ReferencesMamm. Genome, 16, 73-78 (2005). 15859351

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
inadinfantile neuroaxonal dystrophy1inadinfantile neuroaxonal dystrophyinfantile neuroaxonal dystrophy


Donor DNA
Research applicationMouse Models for Human Disease
Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
DepositorYoshibumi Matsushima (Saitama Cancer Center)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Mouse of the Month Mar 2005
Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data