Strain Data Sheet

RBRC00756

Strain Information

Image
BRC No.RBRC00756
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Il2rb<tm1Mak>/Rbrc
Former Common nameIL-2Rβ Knockout mice
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta.
Suzuki H, Kundig T M, Furlonger C, Wakeham A, Timms E, Matsuyama T, Schmits R, Simard J J, Ohashi P S, Griesser H, et a l
Science, 268, 1472-1476 (1995). 7770771

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Il2rb
MGI:96550		interleukin 2 receptor, beta chain15Il2rb<tm1Mak>
MGI:1857193		targeted mutation 1, Tak W Mak
  • immunodeficiency 63 with lymphoproliferation and autoimmunity(MedGEN)
    • neo neomycin resistance gene (E. coli)15 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal B cell activation (MP:0008217)

  • abnormal T cell activation (MP:0001828)

  • abnormal T cell clonal deletion (MP:0005002)

  • abnormal common myeloid progenitor cell morphology (MP:0006410)

  • abnormal hair texture (MP:0002074)
    • more 32 phenotypes
  • abnormal immune system organ morphology (MP:0002722)

  • abnormal locomotor behavior (MP:0001392)

  • abnormal lymphocyte morphology (MP:0002619)

  • abnormal marginal zone B cell morphology (MP:0008180)

  • abnormal mononuclear cell morphology (MP:0008247)

  • abnormal response to transplant (MP:0005671)

  • abnormal sex gland morphology (MP:0000653)

  • abnormal spleen periarteriolar lymphoid sheath morphology (MP:0002358)

  • decreased B cell number (MP:0005017)

  • decreased CD8-positive, alpha-beta T cell number (MP:0008079)

  • decreased T cell proliferation (MP:0005095)

  • decreased double-positive T cell number (MP:0005092)

  • decreased memory T cell number (MP:0008050)

  • decreased regulatory T cell number (MP:0004974)

  • enlarged lymph nodes (MP:0000702)

  • enlarged spleen (MP:0000691)

  • increased CD4-positive, alpha-beta T cell number (MP:0008074)

  • increased CD8-positive, alpha-beta T cell number (MP:0008078)

  • increased IgE level (MP:0002497)

  • increased IgG1 level (MP:0008499)

  • increased activated T cell number (MP:0001829)

  • increased anti-double stranded DNA antibody level (MP:0004762)

  • increased anti-nuclear antigen antibody level (MP:0004794)

  • increased erythroid progenitor cell number (MP:0003135)

  • increased granulocyte number (MP:0000322)

  • increased neutrophil cell number (MP:0000219)

  • increased plasma cell number (MP:0008097)

  • increased susceptibility to autoimmune hemolytic anemia (MP:0004827)

  • liver inflammation (MP:0001860)

  • premature death (MP:0002083)

  • thymus hypoplasia (MP:0001823)

  • weight loss (MP:0001263)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse IL-2R beta genomic DNA, E. coli neo
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The users must disclose the research plan using this resource to the depositor in advance.
    DepositorHaruhiko Suzuki (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Contact Information

    BRC mice in Publications

    No Data