Strain Data Sheet

RBRC00755

Strain Information

Image
BRC No.RBRC00755
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Fcer2a<tm1Kik>/KikRbrc
Former Common nameCD23 Knockout mice
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeveloped by Research Institute, Osaka Medical Center for Maternal and Child Health.
Strain description
Colony maintenance
References
Complete genomic sequence of the murine low affinity Fc receptor for IgE. Demonstration of alternative transcripts and conserved sequence elements.
Richards M L, Katz D H, Liu F T
J. Immunol., 147, 1067-1074 (1991). 1861070

The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice.
Fujiwara H, Kikutani H, Suematsu S, Naka T, Yoshida K, Yoshida K, Tanaka T, Suemura M, Matsumoto N, Kojima S, et a l
Proc. Natl. Acad. Sci. USA, 91, 6835-6839 (1994). 8041705

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Fcer2a
MGI:95497		Fc receptor, IgE, low affinity II, alpha polypeptide8Fcer2a<tm1Kik>
MGI:3583003		targeted mutation 1, Hitoshi Kikutani
neo neomycin resistance gene (E. coli)8 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal cytokine secretion (MP:0003009)

  • abnormal humoral immune response (MP:0001800)

  • abnormal immune system physiology (MP:0001790)

  • increased immunoglobulin level (MP:0002461)
    • Detailed phenotype data

    Ordering Information

    Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, HSV tk poly A (pMC1 neo-poly A GenBank:U43612), mouse CD23 genomic DNA
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 91, 6835-6839 (1994).
    DepositorHitoshi Kikutani (Osaka University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Obayashi K, Doi T, Koyasu S.
    Dendritic cells suppress IgE production in B cells.
    Int Immunol 19(2) 217-26(2007) 17208926