Strain Data Sheet

RBRC00754

Strain Information

Image
BRC No.RBRC00754
TypeTargeted Mutation and TransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Cd40<tm1Kik> Tg(Igh-CD40)1Kik/Rbrc
Former Common nameCD40 transgenic mice
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strain
Appearance
Strain development大阪大学微生物病研究所・菊谷　仁先生（2002）。
Strain descriptionマウスCD40を欠損したヒト野生型CD40トランスジェニックマウス。
Colony maintenance
References
Functional expression of a microinjected Ed alpha gene in C57BL/6 transgenic mice.
K Yamamura, H Kikutani, V Folsom, L K Clayton, M Kimoto, S Akira, S Kashiwamura, S Tonegawa, T Kishimoto
Nature, 316, 67-69 (1985). 2409451

Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals.
Teruhito Yasui, Masaaki Muraoka, Yuko Takaoka-Shichijo, Isao Ishida, Noriko Takegahara, Junji Uchida, Atsushi Kumanogoh, Sachiko Suematsu, Misao Suzuki, Hitoshi Kikutani
Int. Immunol., 14, 319-329 (2002). 11867568

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cd40
MGI:88336		CD40 antigen2Cd40<tm1Kik>
MGI:1857457		targeted mutation 1, Hitoshi Kikutani
  • hyper-IgM syndrome type 3(MedGEN)
    • neo neomycin resistance gene (E. coli)2 herpes simplex virus thymidine kinase promoter (HSV tk promoter)
    CD40 CD40 antigen (human)UNCD40
    MGI:3687555    		mouse E m, IgH promoter, rabbit beta-globin poly A

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal dendritic cell physiology (MP:0002376)

  • abnormal humoral immune response (MP:0001800)

  • absent germinal center B cells (MP:0008179)

  • absent spleen germinal center (MP:0008474)

  • decreased B cell number (MP:0005017)
    • more 15 phenotypes
  • decreased IgA level (MP:0001807)

  • decreased IgE level (MP:0002492)

  • decreased IgG1 level (MP:0008495)

  • decreased IgG2a level (MP:0008496)

  • decreased IgG2b level (MP:0008497)

  • decreased IgG3 level (MP:0008498)

  • decreased bone mineral density (MP:0000063)

  • decreased cerebral infarct size (MP:0006058)

  • decreased compact bone mass (MP:0010962)

  • decreased immunoglobulin level (MP:0002460)

  • decreased neutrophil cell number (MP:0000222)

  • decreased platelet aggregation (MP:0009549)

  • decreased susceptibility to type II hypersensitivity reaction (MP:0005612)

  • decreased trabecular bone mass (MP:0010873)

  • increased susceptibility to bacterial infection (MP:0002412)
    • Detailed phenotype data

    Ordering Information

    供与核酸mouse Em, IgH promoter, human CD40 cDNA, rabbit beta-globin poly A, herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse CD40 genomic DNA
    Research applicationImmunology and Inflammation Research
    提供条件研究成果の公表にあたって寄託者の指定する文献を引用する。Inter. Immunol., 14, 319-329 (2002).
    Depositor菊谷　仁（大阪大学）
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data