Strain Data Sheet
RBRC00753
Strain Information | |
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| Image | |
| BRC No. | RBRC00753 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | B6;129P2-Sema4d<tm1Kik>/Rbrc |
| Former Common name | CD100 Knockout mice |
| H-2 Haplotype | |
| ES Cell line | E14.1 [129P2/OlaHsd] |
| Background strain | |
| Appearance | |
| Strain development | |
| Strain description | |
| Colony maintenance | |
| References | Immunity, 13, 633-642 (2000). 11114376 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |
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| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Sema4dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D13Sema4d<tm1Kik>targeted mutation 1, Hitoshi KikutaniCD100, coll-4, M-sema G, Semacl2, SEMAJ, Semaj, semaphorin H, Semcl2 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)13neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Ordering Information | |
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| 供与核酸 | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse CD100 genomic DNA |
| Research application | |
| 提供条件 | 条件を付加する。 研究成果の公表にあたって寄託者の指定する文献を引用する。Immunity, 13, 633-642 (2000). |
| Depositor | 菊谷 仁（大阪大学） |
| Strain Status |  凍結胚 |
| Strain Availability | 凍結胚より作出したマウスを2~4ヶ月以内に提供可能 凍結胚を1ヶ月以内に提供可能 |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Zhang C, Qiao H, Guo W, Liu Y, Yang L, Liu Y, Jin B, Fu M, Wang G, Li W. CD100-plexin-B1 induces epithelial-mesenchymal transition of head and neck squamous cell carcinoma and promotes metastasis. Cancer Lett 455 1-13(2019) 30981760 Xiao C, Luo Y, Zhang C, Zhu Z, Yang L, Qiao H, Fu M, Wang G, Yao X, Li W. Negative regulation of dendritic cell activation in psoriasis mediated via CD100-plexin-B2. J Pathol 250(4) 409-419(2020) 31943215 Zhu Z, Luo Y, Yu J, Gao J, Zhang Y, Xiao C, Zhang C, Wang G, Liu Y, Fu M, Yao X, Li W. Sema4D is required in both the adaptive and innate immune responses of contact hypersensitivity. Mol Immunol 78 98-104(2016) 27614265 |