Strain Data Sheet

RBRC00702

Strain Information

Image
BRC No.RBRC00702
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S4-Zic1<tm1Jaru>/JaruRbrc
Former Common nameC57BL/6-TgH(Zic1)
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strainC57BL/6JJcl
Appearanceblack
Strain developmentDeveloped by Aruga J (Aruga J et al. J Neurosci 18, 284-293, 1998).The mice were frozen-stored at 2-cell stage after in vitro fertilization between a heterozygous male and C57BL/6J females. Live mice were recovered and born on April 28, 2003.Deposited to RIKEN BioResource Center, RIKEN Tsukuba Institute in 2002.
Strain descriptionZic genes encode zinc finger proteins. These genes are homologs of the Drosophila pair-rule gene odd-paired. This strain was developed to clarify the function of Zic1 gene. Homozygous Zic1 deficient mice show remarkable ataxia during postnatal development, and die within 1 month. Their cerebella are hypoplastic and missing a lobule in the anterior lobe. A bromodeoxyuridine labeling study indicated a reduction both in the proliferating cell fraction in the external germinal layer (EGL), from embryonic day14, and in forward movement of the EGL (Aruga J et al. J Neurosci 18, 284-293, 1998).
Colony maintenanceMice were maintained by successive backcrossing heterozygotes to C57BL/6 mice.
ReferencesJ. Neurosci., 18, 284-293 (1998). 9412507

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Zic1zinc finger protein of the cerebellum 19Zic1<tm1Jaru>targeted mutation 1, Jun Arugazinc finger protein of the cerebellum 1

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)9neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter)

Ordering Information

供与核酸mouse zinc finger protein of the cerebellum 1(nervous system specific transcription factor) Zic1 genomic DNA, mouse phosphoglycerate kinase promoter, E. coli neo
Research application
提供条件条件を付加する。利用者は事前に寄託者の提供承諾書を得る。
研究成果の公表にあたって寄託者の指定する文献を引用する。J. Neurosci., 18, 284-293 (1998).
研究成果の公表にあたって謝辞の表明を必要とする。
Depositor有賀　純（独立行政法人理化学研究所脳科学総合研究センター）
Strain Status凍結胚のアイコン凍結胚
凍結精子のアイコン凍結精子
Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
凍結精子を1ヶ月以内に提供可能
凍結胚を1ヶ月以内に提供可能
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP

BRC mice in Publications

Grinberg I, Northrup H, Ardinger H, Prasad C, Dobyns WB, Millen KJ.
Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation.
Nat Genet 36(10) 1053-5(2004) 15338008