Strain Data Sheet

RBRC00702

Strain Information

Image
BRC No.RBRC00702
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S4-Zic1<tm1Jaru>/JaruRbrc
Former Common nameC57BL/6-TgH(Zic1)
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strainC57BL/6JJcl
Appearanceblack
Strain developmentDeveloped by Aruga J (Aruga J et al. J Neurosci 18, 284-293, 1998).The mice were frozen-stored at 2-cell stage after in vitro fertilization between a heterozygous male and C57BL/6J females. Live mice were recovered and born on April 28, 2003.Deposited to RIKEN BioResource Center, RIKEN Tsukuba Institute in 2002.
Strain descriptionZic genes encode zinc finger proteins. These genes are homologs of the Drosophila pair-rule gene odd-paired. This strain was developed to clarify the function of Zic1 gene. Homozygous Zic1 deficient mice show remarkable ataxia during postnatal development, and die within 1 month. Their cerebella are hypoplastic and missing a lobule in the anterior lobe. A bromodeoxyuridine labeling study indicated a reduction both in the proliferating cell fraction in the external germinal layer (EGL), from embryonic day14, and in forward movement of the EGL (Aruga J et al. J Neurosci 18, 284-293, 1998).
Colony maintenanceMice were maintained by successive backcrossing heterozygotes to C57BL/6 mice.
References
Mouse Zic1 is involved in cerebellar development.
J Aruga, O Minowa, H Yaginuma, J Kuno, T Nagai, T Noda, K Mikoshiba
J. Neurosci., 18, 284-293 (1998). 9412507

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Zic1
MGI:106683		zinc finger protein of the cerebellum 19Zic1<tm1Jaru>
MGI:2156822		targeted mutation 1, Jun Aruga
  • craniosynostosis 6(MedGEN)

  • structural brain anomalies with impaired intellectual development and craniosynostosis(MedGEN)
    • neo neomycin resistance gene (E. coli)9 mouse phosphoglycerate kinase promoter (PGK promoter)

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal cerebellar foliation (MP:0000857)

  • abnormal cerebellum development (MP:0000854)

  • abnormal cerebellum vermis morphology (MP:0000864)

  • abnormal gait (MP:0001406)

  • abnormal suckling behavior (MP:0001436)
    • more 12 phenotypes
  • ataxia (MP:0001393)

  • cerebellum hypoplasia (MP:0000851)

  • decreased locomotor activity (MP:0001402)

  • hypotonia (MP:0004144)

  • impaired limb coordination (MP:0001524)

  • impaired righting response (MP:0001523)

  • kyphosis (MP:0000160)

  • neonatal lethality, incomplete penetrance (MP:0011088)

  • postnatal growth retardation (MP:0001732)

  • postnatal lethality, complete penetrance (MP:0011085)

  • premature death (MP:0002083)

  • reduced cerebellar foliation (MP:0009719)
    • Detailed phenotype data

    Ordering Information

    供与核酸mouse zinc finger protein of the cerebellum 1(nervous system specific transcription factor) Zic1 genomic DNA, mouse phosphoglycerate kinase promoter, E. coli neo
    Research application
    提供条件利用者は事前に寄託者の提供承諾書を得る。研究成果の公表にあたって寄託者の指定する文献を引用する。J. Neurosci., 18, 284-293 (1998). 研究成果の公表にあたって謝辞の表明を必要とする。
    Depositor有賀　純（独立行政法人理化学研究所脳科学総合研究センター）
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP

    BRC mice in Publications

    Grinberg I, Northrup H, Ardinger H, Prasad C, Dobyns WB, Millen KJ.
    Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation.
    Nat Genet 36(10) 1053-5(2004) 15338008