Strain Data Sheet

RBRC00671

Strain Information

Image
BRC No.RBRC00671
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Amd1<tm1Kiga>/Rbrc
Former Common namemouse S-adenosylmethionine decarboxylase gene Knockout mice
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strainC57BL/6
Appearanceblack
Strain development
Strain descriptionHomozygous mutant mice are embryonic lethal.
Colony maintenance
References
Essential role of S-adenosylmethionine decarboxylase in mouse embryonic development.
Nishimura K, Nakatsu F, Kashiwagi K, Ohno H, Saito T, Igarashi K
Genes Cells, 7, 41-47 (2002). 11856372

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Amd1S-adenosylmethionine decarboxylase 110Amd1targeted mutation 1, Kazuei Igarashi
GFPGreen Fluorescent Protein (Aequorea victoria)10
loxPphage P1 loxP10loxP
loxPphage P1 loxP10loxP
neoneomycin resistance gene (E. coli)10

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • embryonic growth arrest(MP:0001730)

  • embryonic lethality between implantation and somite formation, complete penetrance(MP:0011096)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse S-adenosylmethionine decarboxylase genomic DNA, Jellyfish GFP cDNA, E. coli neo, Phage P1 loxP, herpes simplex virus thymidine kinase promoter (HSV tk promoter)
    Research applicationCre/loxP system
    Fluorescent Proteins/lacZ System
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
    The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorKazuei Igarashi (Chiba University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data