Strain Data Sheet

RBRC00639

Strain Information

Image
BRC No.RBRC00639
TypeInbred
SpeciesMus musculus molossinus
Strain nameJF1/Msf
Former Common nameJapanese Fancy 1
H-2 Haplotype
ES Cell line
Background strainJF1 [Mus musculus molossinus]
Appearanceblack spotted white coat, black eyes [a/a B/B C/C D/D s/s]
Strain development日本産由来の愛玩マウス(Japanese Fancy Mouse)を由来とする.1987年,デンマークの市場で売られていたものより,国立遺伝学研究所において系統育成が始められた.1993年にF20代に達する.M. m. mollosinnusに属する.Japanese Fancy Mouse 1
Strain description白色に黒ぶち
Colony maintenance維持は通常の兄妹交配に準ずる。通常、同腹仔の場合は離乳と同時に交配を行う。同腹仔以外の場合は雄8-12週齢,雌4-8週齢(交配未経験の場合)で繁殖に供用するとよい。複数の雄を同ケージで飼育すると激しくケンカをすることがあるので注意が必要である。巣箱や巣材を使用すると繁殖の効率が改善される。交換時にはマウスの移動と同時に前回ケージの巣材も少し移してやるとマウスが安心し、食殺やケンカが軽減できる。
References
A new inbred strain JF1 established from Japanese fancy mouse carrying the classic piebald allele.
T Koide, K Moriwaki, K Uchida, A Mita, T Sagai, H Yonekawa, H Katoh, N Miyashita, K Tsuchiya, T J Nielsen, T Shiroishi
Mamm. Genome, 9, 15-19 (1998). 9434939

The ancestor of extant Japanese fancy mice contributed to the mosaic genomes of classical inbred strains.
Toyoyuki Takada, Toshinobu Ebata, Hideki Noguchi, Thomas M Keane, David J Adams, Takanori Narita, Tadasu Shin-I, Hironori Fujisawa, Atsushi Toyoda, Kuniya Abe, Yuichi Obata, Yoshiyuki Sakaki, Kazuo Moriwaki, Asao Fujiyama, Yuji Kohara, Toshihiko Shiroishi
Genome Res., 23(8), 1329-1338 (2013). 23604024

Health Report

Examination Date / Room / Rack2025/11/17Room:3-CRack:L囮検査
2025/09/08Room:3-CRack:L囮検査
2025/06/30Room:3-CRack:L囮検査
2025/04/21Room:3-CRack:L囮検査
2025/01/20Room:3-CRack:L囮検査
2024/10/21Room:3-CRack:L囮検査
2024/07/22Room:3-CRack:L囮検査
2024/04/22Room:3-CRack:L囮検査

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ednrb
MGI:102720
endothelin receptor type B14Ednrb<s>
MGI:1856148
piebald
  • ABCD syndrome(MedGEN)

  • Hirschsprung disease, susceptibility to, 2(MedGEN)

  • Waardenburg syndrome type 4A(DisGeNET, MedGEN)
  • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal foot pigmentation (MP:0009379)

  • abnormal tail pigmentation (MP:0005174)

  • megacolon (MP:0002731)

  • variable body spotting (MP:0002940)

  • variable depigmentation (MP:0010016)
  • more 1 phenotypes
  • white spotting (MP:0002938)
  • Detailed phenotype data

    Ordering Information

    供与核酸
    Research applicationGenetics Research
    提供条件研究成果の公表にあたって寄託者の指定する文献を引用する。Genome Res., 23, 1329-1338 (2013). 研究成果の公表にあたって謝辞の表明を必要とする。当該リソースを使用した研究成果に基づき特許等の申請を行う場合は、別途協議を行う。利用者は提供承諾書を用いて、事前に寄託者の承諾を得る。(連絡先:マウス開発研究室 小出 剛 <tkoide@nig.ac.jp>)
    Depositor城石 俊彦(国立遺伝学研究所)
    Strain Status生体のアイコン生体
    凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚を1ヶ月以内に提供可能
    生体マウスを1~3ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Tokita S, Watanabe N, Hasegawa A, Funaya S, Miura K, Matoba S, Ogura A, Inoue K.
    Overexpression of Placenta-Specific Noncanonical Imprinted Genes Causes Placental Enlargement in Intersubspecific Hybrid Mice.
    Biol Reprod (2025) 41283858
    Yoshida K, Takada T, Muratani M, Amano T.
    Allele-specific gene expression in F1 hybrid mice reveals structural variants affecting macrophage characteristics.
    Sci Rep 15(1) 37846(2025) 41162494
    Matsuzaki H, Kimura M, Morihashi M, Tanimoto K.
    Imprinted DNA methylation of the H19 ICR is established and maintained in vivo in the absence of Kaiso.
    Epigenetics Chromatin 17(1) 20(2024) 38840164
    Hada M, Miura H, Tanigawa A, Matoba S, Inoue K, Ogonuki N, Hirose M, Watanabe N, Nakato R, Fujiki K, Hasegawa A, Sakashita A, Okae H, Miura K, Shikata D, Arima T, Shirahige K, Hiratani I, Ogura A.
    Highly rigid H3.1/H3.2-H3K9me3 domains set a barrier for cell fate reprogramming in trophoblast stem cells.
    Genes Dev 36(1-2) 84-102(2022) 34992147
    Matsuzaki H, Miyajima Y, Fukamizu A, Tanimoto K.
    Orientation of mouse H19 ICR affects imprinted H19 gene expression through promoter methylation-dependent and -independent mechanisms.
    Commun Biol 4(1) 1410(2021) 34921234
    Matsuzaki H, Kuramochi D, Okamura E, Hirakawa K, Ushiki A, Tanimoto K.
    Recapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locus.
    Epigenetics Chromatin 13(1) 2(2020) 31937365
    Imaizumi Y, Furutachi S, Watanabe T, Miya H, Kawaguchi D, Gotoh Y.
    Role of the imprinted allele of the Cdkn1c gene in mouse neocortical development.
    Sci Rep 10(1) 1884(2020) 32024956
    Sasaki K, Hara S, Yamakami R, Sato Y, Hasegawa S, Kono T, Morohaku K, Obata Y.
    Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice.
    Mol Reprod Dev 86(6) 614-623(2019) 30834655
    Hirose M, Hada M, Kamimura S, Matoba S, Honda A, Motomura K, Ogonuki N, Shawki HH, Inoue K, Takahashi S, Ogura A.
    Aberrant imprinting in mouse trophoblast stem cells established from somatic cell nuclear transfer-derived embryos.
    Epigenetics 13(7) 693-703(2018) 30079806
    Okayama T, Goto T, Toyoda A.
    Assessing nest-building behavior of mice using a 3D depth camera.
    J Neurosci Methods 251 151-7(2015) 26051553
    Kamimura S, Hatanaka Y, Hirasawa R, Matsumoto K, Oikawa M, Lee J, Matoba S, Mizutani E, Ogonuki N, Inoue K, Kohda T, Ishino F, Ogura A.
    Establishment of paternal genomic imprinting in mouse prospermatogonia analyzed by nuclear transfer.
    Biol Reprod 91(5) 120(2014) 25232016
    Hara S, Takano T, Fujikawa T, Yamada M, Wakai T, Kono T, Obata Y.
    Forced expression of DNA methyltransferases during oocyte growth accelerates the establishment of methylation imprints but not functional genomic imprinting.
    Hum Mol Genet 23(14) 3853-64(2014) 24599402
    Mochida K, Hasegawa A, Otaka N, Hama D, Furuya T, Yamaguchi M, Ichikawa E, Ijuin M, Taguma K, Hashimoto M, Takashima R, Kadota M, Hiraiwa N, Mekada K, Yoshiki A, Ogura A.
    Devising assisted reproductive technologies for wild-derived strains of mice: 37 strains from five subspecies of Mus musculus.
    PLoS One 9(12) e114305(2014) 25470728
    Obata Y, Wakai T, Hara S, Kono T.
    Long exposure to mature ooplasm can alter DNA methylation at imprinted loci in non-growing oocytes but not in prospermatogonia.
    Reproduction 147(1) H1-6(2014) 24123131
    Sasaki N, Yamauchi H, Tomohiro N, Agui T.
    The telocentric tandem repeat at the p-arm is not conserved in Mus musculus subspecies.
    Gene 513(1) 214-8(2013) 23116940
    Hasegawa A, Mochida K, Matoba S, Yonezawa K, Ohta A, Watanabe G, Taya K, Ogura A.
    Efficient production of offspring from Japanese wild-derived strains of mice (Mus musculus molossinus) by improved assisted reproductive technologies.
    Biol Reprod 86(5) 167, 1-7(2012) 22337332
    Matoba S, Ogura A.
    Generation of functional oocytes and spermatids from fetal primordial germ cells after ectopic transplantation in adult mice.
    Biol Reprod 84(4) 631-8(2011) 21076079
    Kasahara T, Abe K, Mekada K, Yoshiki A, Kato T.
    Genetic variation of melatonin productivity in laboratory mice under domestication.
    Proc Natl Acad Sci U S A 107(14) 6412-7(2010) 20308563
    Lee J, Kanatsu-Shinohara M, Ogonuki N, Miki H, Inoue K, Morimoto T, Morimoto H, Ogura A, Shinohara T.
    Heritable imprinting defect caused by epigenetic abnormalities in mouse spermatogonial stem cells.
    Biol Reprod 80(3) 518-27(2009) 19020300
    Kim JM, Ogura A.
    Changes in allele-specific association of histone modifications at the imprinting control regions during mouse preimplantation development.
    Genesis 47(9) 611-6(2009) 19530139
    Honda A, Hirose M, Inoue K, Hiura H, Miki H, Ogonuki N, Sugimoto M, Abe K, Kanatsu-Shinohara M, Kono T, Shinohara T, Ogura A.
    Large-scale production of growing oocytes in vitro from neonatal mouse ovaries.
    Int J Dev Biol 53(4) 605-13(2009) 19247970
    Shinmen A, Honda A, Ohkawa M, Hirose M, Ogonuki N, Yuzuriha M, Miki H, Mochida K, Inoue K, Abe K, Ito M, Ogura A.
    Efficient production of intersubspecific hybrid mice and embryonic stem cells by intracytoplasmic sperm injection.
    Mol Reprod Dev 74(9) 1081-8(2007) 17290420
    Inoue K, Ogonuki N, Yamamoto Y, Takano K, Miki H, Mochida K, Ogura A.
    Tissue-specific distribution of donor mitochondrial DNA in cloned mice produced by somatic cell nuclear transfer.
    Genesis 39(2) 79-83(2004) 15170692