Strain Data Sheet

RBRC00610

Strain Information

Image
BRC No.RBRC00610
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameB10.Cg-Gsdma3<Rim3>/Ms
Former Common nameC57BL/10Snf-Rim3/+, B10.Cg-Gsdm3<Rim3>/Ms
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by National Institute of Genetics.
Strain descriptionMouse skin mutant recombination-induced mutation 3. Mutant mice show dominant phenotype of hyperkeratosis and hair loss. A single base G1124A substitution.
Colony maintenance
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Gsdma3
MGI:3044668		gasdermin A311Gsdma3<Rim3>
MGI:1861663		recombination induced mutation 3

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal cornea epithelium morphology(MP:0006000)

  • abnormal cornea stroma development(MP:0003095)

  • abnormal epidermal layer morphology(MP:0001216)

  • abnormal hair cycle anagen phase(MP:0008858)

  • abnormal hair cycle(MP:0000427)
    • more 10 phenotypes
  • abnormal hair growth(MP:0002073)

  • acanthosis(MP:0001874)

  • cornea opacity(MP:0001314)

  • decreased hair follicle number(MP:0000379)

  • disorganized cornea epithelium(MP:0020859)

  • hypergranulosis(MP:0009600)

  • hyperkeratosis(MP:0001242)

  • increased cornea stroma thickness(MP:0009742)

  • sparse hair(MP:0000416)

  • thick epidermis(MP:0001219)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorToshihiko Shiroishi (National Institute of Genetics)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data