Strain Data Sheet

RBRC00468

Strain Information

Image
BRC No.RBRC00468
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(ACTB-CCL2)1Onoe/Rbrc
Former Common namehuman MCP-1 Tgm Line 1
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearanceblack
Strain development
Strain description
Colony maintenance
References
Properties of pro-inflammatory cell type-specific leukocyte chemotactic cytokines, interleukin 8 (IL-8) and monocyte chemotactic and activating factor (MCAF).
Mukaida N, Harada A, Yasumoto K, Matsushima K
Microbiol. Immunol., 36, 773-789 (1992). 1474930

Enhanced contact hypersensitivity in human monocyte chemoattractant protein-1 transgenic mouse.
Mizumoto N, Iwabichi K, Nakamura H, Ato M, Shibaki A, Kawashima T, Kobayashi H, Iwabuchi C, Ohkawara A, Onoe K
Immunobiol., 204, 477-493 (2001). 11776402

Delayed clearance of zymosan-induced granuloma and depressed phagocytosis of macrophages with concomitant up-regulated kinase activities of Src-family in a human monocyte chemoattractant protein-1 transgenic mouse.
Ato M, Iwabuchi K, Matsuki N, Mukaida N, Iwabuchi C, Takahashi A, Takayanagi T, Dondog E A, Hatakeyama S, Ishikura H, Kato M, Negishi I, Nishihori H, Watano K, Ogasawara K, Matsushima K, Onoe K
Immunobiol., 201, 432-449 (2000). 10776798

Augmented expression of tumour necrosis factor-alpha induced by lipopolysaccharide in spleen of human monocyte chemoattractant protein-1 transgenic mouse enhances the lipopolysaccharide sensitivity of the marginal zone macrophages.
Ato M, Iwabuchi K, Shimada S, Mukaida N, Onoe K
Immunology, 106, 554-563 (2002). 12153519

High level monocyte chemoattractant protein-1 expression in transgenic mice increases their susceptibility to intracellular pathogens.
Rutledge B J, Rayburn H, Rosenberg R, North R J, Gladue R P, Corless C L, Rollins B J
J. Immunol., 155, 4838- 4843 (1995). 7594486

A human beta-actin expression vector system directs high-level accumulation of antisense transcripts.
Gunning P, Leavitt J, Muscat G, Ng S Y, Kedes L
Proc. Natl. Acad. Sci. USA, 84, 4831-4835 (1987). 2440031

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
CCL2chemokine (C-C motif) ligand 2 (human)UNCCL2human beta-actin promoter

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal macrophage physiology(MP:0002451)

  • decreased survivor rate(MP:0008770)
  • Detailed phenotype data

    Ordering Information

    Donor DNAhuman monocyte chemotactic and activatingfactor (MCP-1) cDNA, human beta actin promoter, 5'UT, IVS, SV40 poly A
    Research application
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorKazuya Iwabuchi (Hokkaido University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data