Strain Information | |
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Image | |
BRC No. | RBRC00468 |
Type | Transgene |
Species | Mus musculus |
Strain name | B6.Cg-Tg(ACTB-CCL2)1Onoe/Rbrc |
Former Common name | human MCP-1 Tgm Line 1 |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6JJcl |
Appearance | black |
Strain development | |
Strain description | |
Colony maintenance | |
References | Properties of pro-inflammatory cell type-specific leukocyte chemotactic cytokines, interleukin 8 (IL-8) and monocyte chemotactic and activating factor (MCAF). Mukaida N, Harada A, Yasumoto K, Matsushima K Microbiol. Immunol., 36, 773-789 (1992). 1474930Enhanced contact hypersensitivity in human monocyte chemoattractant protein-1 transgenic mouse. Mizumoto N, Iwabichi K, Nakamura H, Ato M, Shibaki A, Kawashima T, Kobayashi H, Iwabuchi C, Ohkawara A, Onoe K Immunobiol., 204, 477-493 (2001). 11776402Delayed clearance of zymosan-induced granuloma and depressed phagocytosis of macrophages with concomitant up-regulated kinase activities of Src-family in a human monocyte chemoattractant protein-1 transgenic mouse. Ato M, Iwabuchi K, Matsuki N, Mukaida N, Iwabuchi C, Takahashi A, Takayanagi T, Dondog E A, Hatakeyama S, Ishikura H, Kato M, Negishi I, Nishihori H, Watano K, Ogasawara K, Matsushima K, Onoe K Immunobiol., 201, 432-449 (2000). 10776798Augmented expression of tumour necrosis factor-alpha induced by lipopolysaccharide in spleen of human monocyte chemoattractant protein-1 transgenic mouse enhances the lipopolysaccharide sensitivity of the marginal zone macrophages. Ato M, Iwabuchi K, Shimada S, Mukaida N, Onoe K Immunology, 106, 554-563 (2002). 12153519High level monocyte chemoattractant protein-1 expression in transgenic mice increases their susceptibility to intracellular pathogens. Rutledge B J, Rayburn H, Rosenberg R, North R J, Gladue R P, Corless C L, Rollins B J J. Immunol., 155, 4838- 4843 (1995). 7594486A human beta-actin expression vector system directs high-level accumulation of antisense transcripts. Gunning P, Leavitt J, Muscat G, Ng S Y, Kedes L Proc. Natl. Acad. Sci. USA, 84, 4831-4835 (1987). 2440031 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
CCL2 | chemokine (C-C motif) ligand 2 (human) | UN | CCL2 | human beta-actin promoter |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | human monocyte chemotactic and activatingfactor (MCP-1) cDNA, human beta actin promoter, 5'UT, IVS, SV40 poly A |
Research application | |
Specific Term and Conditions | No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) |
Depositor | Kazuya Iwabuchi (Hokkaido University) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |