Strain Data Sheet

RBRC00466

Strain Information

Image
BRC No.RBRC00466
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(Ext2*D227N,lacZ)M13Tsh/ShsRbrc
Former Common nameEXT2(D227N) transgenic mice (M13)
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Mouse coq7/clk-1 orthologue rescued slowed rhythmic behavior and extended life span of clk-1 longevity mutant in Caenorhabditis elegans.
Takahashi M, Asaumi S, Honda S, Suzuki Y, Nakai D, Kuroyanagi H, Shimizu T, Honda Y, Shirasawa T
Biochem. Biophys. Res. Commun., 286, 534-540 (2001). 11511092

Transgenic expression of the EXT2 gene in developing chondrocytes enhances the synthesis of heparan sulfate and bone formation in mice.
Morimoto K, Shimizu T, Furukawa K, Morio H, Kurosawa H, Shirasawa T
Biochem. Biophys. Res. Commun., 292, 999-1009 (2002). 11944914

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ext2 exostoses (multiple) 2UNExt2 mouse Col11a2 promoter
lacZ beta-galactosidase (E. coli)UN mouse Col11a2 promoter

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • obsolete no phenotypic analysis(MP:0003012)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse EXT2 (mutant D227N) cDNA, mouse collagen 11a2 promoter region (-742〜+380), SV40 poly A, E. coli lacZ
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The DEPOSITOR should be a co-author in articles when the RECIPIENTs publish their data using these mice for 2 year after provided to the RIKEN BRC.
    The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorTakuji Shirasawa (Tokyo Metropolitan Institute of Gerontology)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese), Lab HP (English)

    BRC mice in Publications

    No Data