Strain Data Sheet

RBRC00440

Strain Information

Image
BRC No.RBRC00440
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Gab1<tm1Thir>/ThirRbrc
Former Common nameGab1 Knockout mice
H-2 Haplotype
ES Cell lineR1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strainC57BL/6JJcl
Appearancegray
yellow
Strain development開発年：2000年　開発者：平野　俊夫先生機関名：大阪大学
Strain description
Colony maintenancehomozygous (Gab1-/-) は胎生致死の為、出生せず。
References
Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation.
Itoh M, Yoshida Y, Nishida K, Narimatsu M, Hibi M, Hirano T
Mol. Cell. Biol., 20, 3695-3704 (2000). 10779359

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Gab1growth factor receptor bound protein 2-associated protein 18Gab1targeted mutation 1, Toshio Hirano
  • autosomal recessive nonsyndromic hearing loss 26(MedGEN)
    • IRESinternal ribosomal entry site (EMCV)8
  • autosomal recessive nonsyndromic hearing loss 26(MedGEN)
    • SASplice acceptor8SA
  • autosomal recessive nonsyndromic hearing loss 26(MedGEN)
    • lacZbeta-galactosidase (E. coli)8
  • autosomal recessive nonsyndromic hearing loss 26(MedGEN)
    • neoneomycin resistance gene (E. coli)8
  • autosomal recessive nonsyndromic hearing loss 26(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal epidermis stratum granulosum morphology(MP:0001239)

  • abnormal hair follicle development(MP:0003704)

  • absent eyelids(MP:0001341)

  • decreased embryo size(MP:0001698)

  • decreased trophoblast giant cell number(MP:0001713)
    • more 12 phenotypes
  • dilated heart left ventricle(MP:0002753)

  • dilated heart right ventricle(MP:0002754)

  • early eyelid opening(MP:0003153)

  • hemopericardium(MP:0005244)

  • hemorrhage(MP:0001914)

  • lethality throughout fetal growth and development, complete penetrance(MP:0011099)

  • petechiae(MP:0008816)

  • placental labyrinth hypoplasia(MP:0001715)

  • small placenta(MP:0004259)

  • thin epidermis(MP:0001218)

  • thin ventricular wall(MP:0000280)

  • ventricular hypoplasia(MP:0000279)
    • Detailed phenotype data

    Ordering Information

    供与核酸SA, Encephalomyocarditis virus (EMCV) internal ribosomal entry site (ires), Bgeo(E. coli lacZ, E. coli neo), mouse Gab1 genomic DNA
    Research applicationFluorescent Proteins/lacZ System
    提供条件利用者は事前に寄託者の提供承諾書を得る。研究成果の公表にあたって寄託者の指定する文献を引用する。研究成果の公表にあたって謝辞の表明を必要とする。公表を前提とした学術研究に限る。
    共著を必要とする共同研究は寄託後1年間に限定する。
    利用者が当該リソースを使用した研究成果に基づく特許等の申請を行う場合は、寄託者と別途協議を行う。
    Depositor平野　俊夫（大阪大学）
    Strain Status凍結胚のアイコン凍結胚
    凍結精子のアイコン凍結精子
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結精子を1ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data