Strain Information | |
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Image | |
BRC No. | RBRC00407 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129P2-Tcrd<tm1Mom>/ItoRbrc |
Former Common name | TCR delta-KO, TCRd KO |
H-2 Haplotype | |
ES Cell line | E14 [129P2/OlaHsd] |
Background strain | C57BL/6JJcl |
Appearance | black [a/a B/B C/C] |
Strain development | 1993年、糸原重美先生、MIT |
Strain description | γδT細胞を欠損する。 |
Colony maintenance | 繁殖効率:A特になし |
References | Cell, 72, 337-348 (1993). 8381716 |
Health Report | |
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Examination Date / Room / Rack | 2024/02/05Room:2-検Rack:G 2023/11/06Room:2-検Rack:G |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter TcrdT-cell receptor delta chain14Tcrd<tm1Mom>targeted mutation 1, Peter MombaertsTcr delta, Tcrdelta Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)14neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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供与核酸 | mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse T-cell receptor delta chain genome DNA |
Research application | Cell Biology Research Immunology and Inflammation Research |
提供条件 | 条件を付加する。 研究成果の公表にあたって寄託者の指定する文献を引用する。Itohara et al., Cell, 72, 337-348 (1993). |
Depositor | 糸原 重美(理化学研究所脳科学総合研究センター) |
Strain Status | 凍結胚 凍結精子 |
Strain Availability | 凍結胚より作出したマウスを2~4ヶ月以内に提供可能 凍結精子を1ヶ月以内に提供可能 凍結胚を1ヶ月以内に提供可能 |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Segawa S, Goto D, Yoshiga Y, Horikoshi M, Sugihara M, Hayashi T, Chino Y, Matsumoto I, Ito S, Sumida T. Involvement of NK 1.1-positive γδT cells in interleukin-18 plus interleukin-2-induced interstitial lung disease. Am J Respir Cell Mol Biol 45(3) 659-66(2011) 21257923 Segawa S, Goto D, Iizuka A, Kaneko S, Yokosawa M, Kondo Y, Matsumoto I, Sumida T. The regulatory role of interferon-γ producing gamma delta T cells via the suppression of T helper 17 cell activity in bleomycin-induced pulmonary fibrosis. Clin Exp Immunol 185(3) 348-60(2016) 27083148 |