Strain Data Sheet

RBRC00407

Strain Information

Image
BRC No.RBRC00407
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Tcrd<tm1Mom>/ItoRbrc
Former Common nameTCR delta-KO, TCRd KO
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Drs. S. Itohara, P. Mombaerts and S Tonegawa, Howard Hughes Medical Institute, Massachusetts Institute of Technology in 1993.
Strain descriptionDeveloped by Drs. S. Itohara, P. Mombaerts and S Tonegawa, Howard Hughes Medical Institute, Massachusetts Institute of Technology in 1993.
Colony maintenanceSibling MatingHomozygous mutant mice are viable and fertile.
References
T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes.
Itohara S, Mombaerts P, Lafaille J, Iacomini J, Nelson A, Clarke A R, Hooper M L, Farr A, Tonegawa S
Cell, 72, 337-348 (1993). 8381716

Health Report

Examination Date / Room / Rack2024/05/07Room:2-検Rack:GSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tcrd
MGI:98611		T cell receptor delta chain14Tcrd<tm1Mom>
MGI:1857257		targeted mutation 1, Peter Mombaerts
neo neomycin resistance gene (E. coli)14 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal gamma-delta T cell differentiation (MP:0008356)

  • abnormal respiratory system physiology (MP:0002133)

  • abnormal skin condition (MP:0001191)

  • absent gamma-delta T cells (MP:0008348)

  • dermatitis (MP:0001194)
    • more 2 phenotypes
  • impaired skin barrier function (MP:0002796)

  • increased apoptosis (MP:0006042)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse T-cell receptor delta chain genome DNA
    Research applicationCell Biology Research
    Immunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell, 72, 337-348 (1993).
    DepositorShigeyoshi Itohara (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Ibraheem Y, Bayarsaikhan G, Macalinao ML, Kimura K, Yui K, Aoshi T, Inoue SI.
    γδ T cell-mediated activation of cDC1 orchestrates CD4+ Th1 cell priming in malaria.
    Front Immunol 15 1426316(2024) 39211036
    Segawa S, Goto D, Iizuka A, Kaneko S, Yokosawa M, Kondo Y, Matsumoto I, Sumida T.
    The regulatory role of interferon-γ producing gamma delta T cells via the suppression of T helper 17 cell activity in bleomycin-induced pulmonary fibrosis.
    Clin Exp Immunol 185(3) 348-60(2016) 27083148
    Segawa S, Goto D, Yoshiga Y, Horikoshi M, Sugihara M, Hayashi T, Chino Y, Matsumoto I, Ito S, Sumida T.
    Involvement of NK 1.1-positive γδT cells in interleukin-18 plus interleukin-2-induced interstitial lung disease.
    Am J Respir Cell Mol Biol 45(3) 659-66(2011) 21257923