Strain Data Sheet

RBRC00407

Information1

Image
BRC No.RBRC00407
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Tcrd<tm1Mom>/ItoRbrc
Former Common nameTCR delta-KO, TCRd KO
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Drs. S. Itohara, P. Mombaerts and S Tonegawa, Howard Hughes Medical Institute, Massachusetts Institute of Technology in 1993.
Strain descriptionDeveloped by Drs. S. Itohara, P. Mombaerts and S Tonegawa, Howard Hughes Medical Institute, Massachusetts Institute of Technology in 1993.
Colony maintenanceSibling MatingHomozygous mutant mice are viable and fertile.
ReferencesCell, 72, 337-348 (1993). 8381716

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
TcrdT-cell receptor delta chain14Tcrd<tm1Mom>targeted mutation 1, Peter MombaertsTcr delta, Tcrdelta

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)14neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter)

Information2

Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse T-cell receptor delta chain genome DNA
Research applicationCell Biology Research
Immunology and Inflammation Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Itohara et al., Cell, 72, 337-348 (1993).
DepositorShigeyoshi Itohara (RIKEN)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

Segawa S, Goto D, Yoshiga Y, Horikoshi M, Sugihara M, Hayashi T, Chino Y, Matsumoto I, Ito S, Sumida T.
Involvement of NK 1.1-positive γδT cells in interleukin-18 plus interleukin-2-induced interstitial lung disease.
Am J Respir Cell Mol Biol 45(3) 659-66(2011) 21257923

Segawa S, Goto D, Iizuka A, Kaneko S, Yokosawa M, Kondo Y, Matsumoto I, Sumida T.
The regulatory role of interferon-γ producing gamma delta T cells via the suppression of T helper 17 cell activity in bleomycin-induced pulmonary fibrosis.
Clin Exp Immunol 185(3) 348-60(2016) 27083148