Strain Data Sheet

RBRC00389

Strain Information

Image
BRC No.RBRC00389
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameSHM/Nem-Re/+-shm/+
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Enhancement of 5-hydroxytryptamine turnover in descending serotonergic neurons of shambling mutant mice.
T Kumazawa, K Adachi, K Ando, S Oda
Neurochem. Int., 11, 283-286 (1987). 20501172

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cntnap1
MGI:1858201		contactin associated protein-like 111Cntnap1
MGI:1857037		shambling
  • lethal congenital contracture syndrome 7(MedGEN)

  • neuropathy, congenital hypomyelinating, 3(MedGEN)
    • Krt25
    MGI:97888    		rex11Krt25
    MGI:1856137    		rex

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal axon morphology (MP:0005404)

  • abnormal gait (MP:0001406)

  • abnormal limb posture (MP:0004263)

  • abnormal motor coordination/balance (MP:0001516)

  • abnormal nerve conduction (MP:0005403)
    • more 18 phenotypes
  • abnormal node of Ranvier morphology (MP:0010732)

  • abnormal paranodal axoglial junction morphology (MP:0010735)

  • abnormal paranode morphology (MP:0010734)

  • abnormal resting posture (MP:0009393)

  • abnormal visual evoked potential (MP:0010748)

  • ataxia (MP:0001393)

  • curly vibrissae (MP:0001274)

  • decreased body size (MP:0001265)

  • decreased locomotor activity (MP:0001402)

  • decreased nerve conduction velocity (MP:0008814)

  • decreased survivor rate (MP:0008770)

  • impaired coordination (MP:0001405)

  • impaired limb coordination (MP:0001524)

  • impaired swimming (MP:0001522)

  • lethality at weaning, complete penetrance (MP:0011083)

  • reduced fertility (MP:0001921)

  • tremors (MP:0000745)

  • waved hair (MP:0000410)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationNeurobiology Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
    DepositorSenichi Oda (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data