Strain Data Sheet

RBRC00388

update : 2024-04-19

Strain Information
Image
BRC No.	RBRC00388
Type	Spontaneous Mutation
Species	Mus musculus
Strain name	PROD-Cacna1a<tg-rol>/NemOdaRbrc
Former Common name	PROD-rol/+
H-2 Haplotype
ES Cell line
Background strain
Appearance	agouti with white spot [A/A B/? C/C s/s]
Strain development	乳仔死亡の多発を特性とするSIIIとC57BL/6Ngaとを交配し（1967年），1969年，この交配の後代（6世代目）に，歩行異常マウスが出現（名古屋大学農学部）．その後，名古屋大学環境医学研究所（織田銑一先生）を経て，理研BRCに導入された。
Strain description	rol: Rolling mouse Nagoya　遺伝性運動失調症Cchl1a4<tg>遺伝子座 (第8染色体) におけるミュータント．tg: tottering mouse (小脳性運動失調症) の複対立遺伝子 (tgrol) ．劣性単一遺伝子．小脳性失調．生後10‐14日に歩行異常が起こる．特に後肢のアンバランスが著しく，横転を繰り返す．
Colony maintenance	Rollingの♀は繁殖可能で交配に使えるが，繁殖能力や哺育能力は正常個体と比べると劣る．Rollingの♂は交尾動作が不調で交配に用いるのは難しい．哺乳期に正常個体と同居させておくとRollingの成育はよくない．
References	Neurosci. Lett., 266, 49-52 (1999). 10336181 J. Neurosci., 20, 5654-5662 (2000). 10908603 Dev. Psycobiology, 19, 67-77 (1986). 3699253 Neurosci. Res., 5, 316-324 (1988). 2897649 Genetic Approches to Developmental Neurobiology (TSUKADA Yasuzo, ed), University of Tokyo Press, Tokyo, pp. 171-181 (1982). 実験動物, 22, 281-288 (1973). チャンネル病, 脳の科学(1999年増刊号), 星和書店, 東京, 101-106 (1999). Jpn. J. Genet., 56, 295-299 (1981). 名古屋大学環境医学研究所年報, 27, 195-197 (1976). 医学のあゆみ, 101, 74-75 (1977). 実験動物の遺伝的コントロール（富田武，江崎考三郎，早川純一郎，編）ソフトサイエンス社，　東京， pp. 248-259 (1983). 名古屋大学環境医学研究所年報, 26, 7-9 (1975). Biomed. Res., 1, 88-90 (1980). 名古屋大学環境医学研究所年報, 27, 193-194 (1976). 名古屋大学環境医学研究所年報, 28, 212-213 (1977).

Health Report
Examination Date / Room / Rack

Gene
Gene info	Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit8Cacna1a<tg-rol>rolling Nagoyaalpha1A, Cacnl1a4, Ccha1a, EA2, MHP1, nmf352, SCA6

Ordering Information
供与核酸
Research application	Developmental Biology Research Genetics Research Mouse Models for Human Disease Neurobiology Research
提供条件	条件を付加する。利用者は事前に寄託者の提供承諾書を得る。利用者が当該リソースを使用した研究成果に基づく特許等の申請を行う場合は、寄託者と別途協議を行う。
Depositor	織田　銑一（名古屋大学）
Strain Status	凍結胚
Strain Availability	凍結胚より作出したマウスを2~4ヶ月以内に提供可能凍結胚を1ヶ月以内に提供可能
Additional Info.	Necessary documents for ordering: Approval form (Japanese / English) Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

BRC mice in Publications

Niimi K, Han Y, Zhou Y, Yoshimoto T, Dai F, Teng X, Tian X, Li W, Takahashi E. Blockade of Cav2.1-mediated NMDA receptor signaling disrupts conditioned fear extinction. Behav Brain Res 259 45-9(2014) 24177210 Takahashi E, Niimi K, Itakura C. Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya. Behav Brain Res 204(1) 241-5(2009) 19467269 Tian X, Zhou Y, Gao L, He G, Jiang W, Li W, Takahashi E. Analysis of ischemic neuronal injury in Cav2.1 channel α1 subunit mutant mice. Biochem Biophys Res Commun 434(1) 60-4(2013) 23545255 Goriely S, Molle C, Nguyen M, Albarani V, Haddou NO, Lin R, De Wit D, Flamand V, Willems F, Goldman M. Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation. Blood 107(3) 1078-84(2006) 16219795 Kim TY, Niimi K, Takahashi E. Analysis of the protective effects of the α2/δ subunit of voltage-gated Ca2+ channels in brain injury. Brain Res 1655 138-144(2017) 27840189 Takahashi E, Niimi K, Itakura C. Motor coordination impairment in aged heterozygous rolling Nagoya, Cav2.1 mutant mice. Brain Res 1279 50-7(2009) 19446536 Takahashi E, Niimi K. Spatial learning deficit in aged heterozygous Cav2.1 channel mutant mice, rolling mouse Nagoya. Exp Gerontol 44(4) 274-9(2009) 19073246 Takahashi E, Niimi K, Itakura C. Interaction between Ca(v)2.1alpha (1) and CaMKII in Ca (v)2.1alpha (1) mutant mice, Rolling Nagoya. J Mol Neurosci 41(2) 223-9(2010) 19609731 Fukumoto N, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I. Ca2+ channel currents in dorsal root ganglion neurons of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya. Neurosci Res 73(3) 199-206(2012) 22575052 Fukumoto N, Obama Y, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I. Hypoalgesic behaviors of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya. Neuroscience 160(1) 165-73(2009) 19248821

BRC mice in Publications

Niimi K, Han Y, Zhou Y, Yoshimoto T, Dai F, Teng X, Tian X, Li W, Takahashi E.
Blockade of Cav2.1-mediated NMDA receptor signaling disrupts conditioned fear extinction.
Behav Brain Res 259 45-9(2014) 24177210

Takahashi E, Niimi K, Itakura C.
Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya.
Behav Brain Res 204(1) 241-5(2009) 19467269

Tian X, Zhou Y, Gao L, He G, Jiang W, Li W, Takahashi E.
Analysis of ischemic neuronal injury in Cav2.1 channel α1 subunit mutant mice.
Biochem Biophys Res Commun 434(1) 60-4(2013) 23545255

Goriely S, Molle C, Nguyen M, Albarani V, Haddou NO, Lin R, De Wit D, Flamand V, Willems F, Goldman M.
Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation.
Blood 107(3) 1078-84(2006) 16219795

Kim TY, Niimi K, Takahashi E.
Analysis of the protective effects of the α2/δ subunit of voltage-gated Ca2+ channels in brain injury.
Brain Res 1655 138-144(2017) 27840189

Takahashi E, Niimi K, Itakura C.
Motor coordination impairment in aged heterozygous rolling Nagoya, Cav2.1 mutant mice.
Brain Res 1279 50-7(2009) 19446536

Takahashi E, Niimi K.
Spatial learning deficit in aged heterozygous Cav2.1 channel mutant mice, rolling mouse Nagoya.
Exp Gerontol 44(4) 274-9(2009) 19073246

Takahashi E, Niimi K, Itakura C.
Interaction between Ca(v)2.1alpha (1) and CaMKII in Ca (v)2.1alpha (1) mutant mice, Rolling Nagoya.
J Mol Neurosci 41(2) 223-9(2010) 19609731

Fukumoto N, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I.
Ca2+ channel currents in dorsal root ganglion neurons of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya.
Neurosci Res 73(3) 199-206(2012) 22575052

Fukumoto N, Obama Y, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I.
Hypoalgesic behaviors of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya.
Neuroscience 160(1) 165-73(2009) 19248821

Strain Information

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BRC mice in Publications