Strain Data Sheet

RBRC00388

Strain Information

Image
BRC No.RBRC00388
TypeSpontaneous Mutation
SpeciesMus musculus
Strain namePROD-Cacna1a<tg-rol>/NemOdaRbrc
Former Common namePROD-rol/+
H-2 Haplotype
ES Cell line
Background strain
Appearanceagouti with white spot [A/A B/? C/C s/s]
Strain development乳仔死亡の多発を特性とするSIIIとC57BL/6Ngaとを交配し（1967年），1969年，この交配の後代（6世代目）に，歩行異常マウスが出現（名古屋大学農学部）．その後，名古屋大学環境医学研究所（織田銑一先生）を経て，理研BRCに導入された。
Strain descriptionrol: Rolling mouse Nagoya　遺伝性運動失調症Cchl1a4<tg>遺伝子座 (第8染色体) におけるミュータント．tg: tottering mouse (小脳性運動失調症) の複対立遺伝子 (tgrol) ．劣性単一遺伝子．小脳性失調．生後10‐14日に歩行異常が起こる．特に後肢のアンバランスが著しく，横転を繰り返す．
Colony maintenanceRollingの♀は繁殖可能で交配に使えるが，繁殖能力や哺育能力は正常個体と比べると劣る．Rollingの♂は交尾動作が不調で交配に用いるのは難しい．哺乳期に正常個体と同居させておくとRollingの成育はよくない．
References
実験動物, 22, 281-288 (1973).

名古屋大学環境医学研究所年報, 26, 7-9 (1975).

名古屋大学環境医学研究所年報, 27, 195-197 (1976).

名古屋大学環境医学研究所年報, 27, 193-194 (1976).

名古屋大学環境医学研究所年報, 28, 212-213 (1977).

医学のあゆみ, 101, 74-75 (1977).

Biomed. Res., 1, 88-90 (1980).

Jpn. J. Genet., 56, 295-299 (1981).

Genetic Approches to Developmental Neurobiology (TSUKADA Yasuzo, ed), University of Tokyo Press, Tokyo, pp. 171-181 (1982).

実験動物の遺伝的コントロール（富田武，江崎考三郎，早川純一郎，編）ソフトサイエンス社，　東京， pp. 248-259 (1983).
more 5 references
Postnatal locomotion development in a neurological mutant of rolling mouse Nagoya.
Tamaki Y, Oda S, Kameyama Y
Dev. Psycobiology, 19, 67-77 (1986). 3699253

Neurotransmitter receptors of the rolling mouse Nagoya: a quantitative autoradiographic study.
Onodera H, Takase S, Oda S, Sobue I, Kogure K
Neurosci. Res., 5, 316-324 (1988). 2897649

Morphologic investigation of rolling mouse Nagoya (tg(rol)/tg(rol)) cerebellar Purkinje cells: an ataxic mutant, revisited.
Rhyu I J, Oda S, Uhm C S, Kim H, Suh Y S, Abbott L C
Neurosci. Lett., 266, 49-52 (1999). 10336181

チャンネル病, 脳の科学(1999年増刊号), 星和書店, 東京, 101-106 (1999).

Reduced voltage sensitivity of activation of P/Q-type Ca2+ channels is associated with the ataxic mouse mutation rolling Nagoya (tg(rol)).
Mori Y, Wakamori M, Oda S, Fletcher C F, Sekiguchi N, Mori E, Copeland N G, Jenkins N A, Matsushita K, Matsuyama Z, Imoto K
J. Neurosci., 20, 5654-5662 (2000). 10908603

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cacna1a
MGI:109482		calcium channel, voltage-dependent, P/Q type, alpha 1A subunit8Cacna1a<tg-rol>
MGI:1856211		rolling Nagoya
  • developmental and epileptic encephalopathy, 42(MedGEN)

  • episodic ataxia type 2(DisGeNET, MedGEN)

  • migraine, familial hemiplegic, 1(DisGeNET, MedGEN)
    • more 1 Diseases
  • spinocerebellar ataxia type 6(DisGeNET, MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal CNS synaptic transmission (MP:0002206)

  • abnormal amino acid level (MP:0005332)

  • abnormal brainstem morphology (MP:0005277)

  • abnormal cerebellum morphology (MP:0000849)

  • abnormal enzyme/coenzyme activity (MP:0005584)
    • more 27 phenotypes
  • abnormal excitatory postsynaptic currents (MP:0002910)

  • abnormal glucose homeostasis (MP:0002078)

  • abnormal metabolism (MP:0005266)

  • abnormal miniature excitatory postsynaptic currents (MP:0004753)

  • abnormal muscle electrophysiology (MP:0004145)

  • abnormal nervous system physiology (MP:0003633)

  • abnormal noradrenaline level (MP:0003964)

  • abnormal nursing (MP:0001382)

  • abnormal response/metabolism to endogenous compounds (MP:0003638)

  • ataxia (MP:0001393)

  • cerebellum atrophy (MP:0014185)

  • cerebellum hypoplasia (MP:0000851)

  • decreased body weight (MP:0001262)

  • decreased choline O-acetyltransferase activity (MP:0012590)

  • decreased glutamic acid level (MP:0030737)

  • enhanced paired-pulse facilitation (MP:0002919)

  • impaired limb coordination (MP:0001524)

  • increased apoptosis (MP:0006042)

  • increased brain tyrosine 3-monooxygenase activity (MP:0020076)

  • increased glycine level (MP:0030658)

  • increased noradrenaline level (MP:0012575)

  • increased taurine level (MP:0030635)

  • muscle weakness (MP:0000747)

  • reduced female fertility (MP:0001923)

  • reduced male fertility (MP:0001922)

  • small cerebellum (MP:0000852)

  • weakness (MP:0000746)
    • Detailed phenotype data

    Ordering Information

    供与核酸
    Research applicationDevelopmental Biology Research
    Genetics Research
    Mouse Models for Human Disease
    Neurobiology Research
    提供条件利用者は事前に寄託者の提供承諾書を得る。利用者が当該リソースを使用した研究成果に基づく特許等の申請を行う場合は、寄託者と別途協議を行う。
    Depositor織田　銑一（名古屋大学）
    Strain Status凍結胚のアイコン凍結胚
    Strain Availability凍結胚より作出したマウスを2~4ヶ月以内に提供可能
    凍結胚を1ヶ月以内に提供可能
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    Kim TY, Niimi K, Takahashi E.
    Analysis of the protective effects of the α2/δ subunit of voltage-gated Ca2+ channels in brain injury.
    Brain Res 1655 138-144(2017) 27840189
    Niimi K, Han Y, Zhou Y, Yoshimoto T, Dai F, Teng X, Tian X, Li W, Takahashi E.
    Blockade of Cav2.1-mediated NMDA receptor signaling disrupts conditioned fear extinction.
    Behav Brain Res 259 45-9(2014) 24177210
    Tian X, Zhou Y, Gao L, He G, Jiang W, Li W, Takahashi E.
    Analysis of ischemic neuronal injury in Cav2.1 channel α1 subunit mutant mice.
    Biochem Biophys Res Commun 434(1) 60-4(2013) 23545255
    Fukumoto N, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I.
    Ca2+ channel currents in dorsal root ganglion neurons of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya.
    Neurosci Res 73(3) 199-206(2012) 22575052
    Takahashi E, Niimi K, Itakura C.
    Interaction between Ca(v)2.1alpha (1) and CaMKII in Ca (v)2.1alpha (1) mutant mice, Rolling Nagoya.
    J Mol Neurosci 41(2) 223-9(2010) 19609731
    Takahashi E, Niimi K, Itakura C.
    Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya.
    Behav Brain Res 204(1) 241-5(2009) 19467269
    Takahashi E, Niimi K, Itakura C.
    Motor coordination impairment in aged heterozygous rolling Nagoya, Cav2.1 mutant mice.
    Brain Res 1279 50-7(2009) 19446536
    Takahashi E, Niimi K.
    Spatial learning deficit in aged heterozygous Cav2.1 channel mutant mice, rolling mouse Nagoya.
    Exp Gerontol 44(4) 274-9(2009) 19073246
    Fukumoto N, Obama Y, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I.
    Hypoalgesic behaviors of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya.
    Neuroscience 160(1) 165-73(2009) 19248821
    Goriely S, Molle C, Nguyen M, Albarani V, Haddou NO, Lin R, De Wit D, Flamand V, Willems F, Goldman M.
    Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation.
    Blood 107(3) 1078-84(2006) 16219795