Strain Data Sheet

RBRC00388

update : 2023-05-22

Information1
Image
BRC No.	RBRC00388
Type	Spontaneous Mutation
Species	Mus musculus
Strain name	PROD-Cacna1a<tg-rol>/NemOdaRbrc
Former Common name	PROD-rol/+
H-2 Haplotype
ES Cell line
Background strain
Appearance	agouti with white spot [A/A B/? C/C s/s]
Strain development	Developed by Dr. Sen-ichi Oda, Nagoya University. Cacna1a<tg-rol> arose spontaneously in descendants of (SIII x C57BL/6)F1 in 1969.
Strain description	Rolling mouse Nagoya, PROD-Cacna1a<tg-rol>/NemOdaRbrc. Cacna1a gene is a voltage-gated pore-forming membrane protein, mediates Ca2+ influx across presynaptic and somatodendritic membranes, thereby triggering fast neurotransmitter release and other key neuronal responses. Homozygous mutant mice exhibit a severe ataxia, episodic dyskinesia, and cerebellar atrophy.
Colony maintenance	Homozygous mutant mice are identifiable between 10 and 14 days old by a creeping or rolling gait.homozygous females are fertile but do not breed well.
References	Neurosci. Res., 5, 316-324 (1988). 2897649 J. Neurosci., 20, 5654-5662 (2000). 10908603 Dev. Psycobiology, 19, 67-77 (1986). 3699253 Neurosci. Lett., 266, 49-52 (1999). 10336181 Genetic Approches to Developmental Neurobiology (TSUKADA Yasuzo, ed), University of Tokyo Press, Tokyo, pp. 171-181 (1982). 医学のあゆみ, 101, 74-75 (1977). チャンネル病, 脳の科学(1999年増刊号), 星和書店, 東京, 101-106 (1999). 名古屋大学環境医学研究所年報, 27, 195-197 (1976). 実験動物の遺伝的コントロール（富田武，江崎考三郎，早川純一郎，編）ソフトサイエンス社，　東京， pp. 248-259 (1983). Jpn. J. Genet., 56, 295-299 (1981). 名古屋大学環境医学研究所年報, 26, 7-9 (1975). 実験動物, 22, 281-288 (1973). Biomed. Res., 1, 88-90 (1980). 名古屋大学環境医学研究所年報, 27, 193-194 (1976). 名古屋大学環境医学研究所年報, 28, 212-213 (1977).

Health Report
Examination Date / Room / Rack

Gene
Gene info	Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit8Cacna1a<tg-rol>rolling Nagoyaalpha1A, Cacnl1a4, Ccha1a, EA2, MHP1, nmf352, SCA6

Information2
Donor DNA
Research application	Developmental Biology Research Genetics Research Neurobiology Research
Specific Term and Conditions	The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Depositor	Senichi Oda (Nagoya University)
Strain Status	Frozen embryos
Strain Availability	Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month)
Additional Info.	Necessary documents for ordering: Approval form (Japanese / English) Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

BRC mice in Publications

Niimi K, Han Y, Zhou Y, Yoshimoto T, Dai F, Teng X, Tian X, Li W, Takahashi E. Blockade of Cav2.1-mediated NMDA receptor signaling disrupts conditioned fear extinction. Behav Brain Res 259 45-9(2014) 24177210 Takahashi E, Niimi K, Itakura C. Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya. Behav Brain Res 204(1) 241-5(2009) 19467269 Tian X, Zhou Y, Gao L, He G, Jiang W, Li W, Takahashi E. Analysis of ischemic neuronal injury in Cav2.1 channel α1 subunit mutant mice. Biochem Biophys Res Commun 434(1) 60-4(2013) 23545255 Goriely S, Molle C, Nguyen M, Albarani V, Haddou NO, Lin R, De Wit D, Flamand V, Willems F, Goldman M. Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation. Blood 107(3) 1078-84(2006) 16219795 Kim TY, Niimi K, Takahashi E. Analysis of the protective effects of the α2/δ subunit of voltage-gated Ca2+ channels in brain injury. Brain Res 1655 138-144(2017) 27840189 Takahashi E, Niimi K, Itakura C. Motor coordination impairment in aged heterozygous rolling Nagoya, Cav2.1 mutant mice. Brain Res 1279 50-7(2009) 19446536 Takahashi E, Niimi K. Spatial learning deficit in aged heterozygous Cav2.1 channel mutant mice, rolling mouse Nagoya. Exp Gerontol 44(4) 274-9(2009) 19073246 Takahashi E, Niimi K, Itakura C. Interaction between Ca(v)2.1alpha (1) and CaMKII in Ca (v)2.1alpha (1) mutant mice, Rolling Nagoya. J Mol Neurosci 41(2) 223-9(2010) 19609731 Fukumoto N, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I. Ca2+ channel currents in dorsal root ganglion neurons of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya. Neurosci Res 73(3) 199-206(2012) 22575052 Fukumoto N, Obama Y, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I. Hypoalgesic behaviors of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya. Neuroscience 160(1) 165-73(2009) 19248821

BRC mice in Publications

Niimi K, Han Y, Zhou Y, Yoshimoto T, Dai F, Teng X, Tian X, Li W, Takahashi E.
Blockade of Cav2.1-mediated NMDA receptor signaling disrupts conditioned fear extinction.
Behav Brain Res 259 45-9(2014) 24177210

Takahashi E, Niimi K, Itakura C.
Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya.
Behav Brain Res 204(1) 241-5(2009) 19467269

Tian X, Zhou Y, Gao L, He G, Jiang W, Li W, Takahashi E.
Analysis of ischemic neuronal injury in Cav2.1 channel α1 subunit mutant mice.
Biochem Biophys Res Commun 434(1) 60-4(2013) 23545255

Goriely S, Molle C, Nguyen M, Albarani V, Haddou NO, Lin R, De Wit D, Flamand V, Willems F, Goldman M.
Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation.
Blood 107(3) 1078-84(2006) 16219795

Kim TY, Niimi K, Takahashi E.
Analysis of the protective effects of the α2/δ subunit of voltage-gated Ca2+ channels in brain injury.
Brain Res 1655 138-144(2017) 27840189

Takahashi E, Niimi K, Itakura C.
Motor coordination impairment in aged heterozygous rolling Nagoya, Cav2.1 mutant mice.
Brain Res 1279 50-7(2009) 19446536

Takahashi E, Niimi K.
Spatial learning deficit in aged heterozygous Cav2.1 channel mutant mice, rolling mouse Nagoya.
Exp Gerontol 44(4) 274-9(2009) 19073246

Takahashi E, Niimi K, Itakura C.
Interaction between Ca(v)2.1alpha (1) and CaMKII in Ca (v)2.1alpha (1) mutant mice, Rolling Nagoya.
J Mol Neurosci 41(2) 223-9(2010) 19609731

Fukumoto N, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I.
Ca2+ channel currents in dorsal root ganglion neurons of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya.
Neurosci Res 73(3) 199-206(2012) 22575052

Fukumoto N, Obama Y, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I.
Hypoalgesic behaviors of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya.
Neuroscience 160(1) 165-73(2009) 19248821

Information1

Health Report

Gene

Information2

BRC mice in Publications