Strain Information | |
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Image | |
BRC No. | RBRC00388 |
Type | Spontaneous Mutation |
Species | Mus musculus |
Strain name | PROD-Cacna1a<tg-rol>/NemOdaRbrc |
Former Common name | PROD-rol/+ |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | agouti with white spot [A/A B/? C/C s/s] |
Strain development | Developed by Dr. Sen-ichi Oda, Nagoya University. Cacna1a<tg-rol> arose spontaneously in descendants of (SIII x C57BL/6)F1 in 1969. |
Strain description | Rolling mouse Nagoya, PROD-Cacna1a<tg-rol>/NemOdaRbrc. Cacna1a gene is a voltage-gated pore-forming membrane protein, mediates Ca2+ influx across presynaptic and somatodendritic membranes, thereby triggering fast neurotransmitter release and other key neuronal responses. Homozygous mutant mice exhibit a severe ataxia, episodic dyskinesia, and cerebellar atrophy. |
Colony maintenance | Homozygous mutant mice are identifiable between 10 and 14 days old by a creeping or rolling gait.homozygous females are fertile but do not breed well. |
References | Morphologic investigation of rolling mouse Nagoya (tg(rol)/tg(rol)) cerebellar Purkinje cells: an ataxic mutant, revisited. Rhyu I J, Oda S, Uhm C S, Kim H, Suh Y S, Abbott L C Neurosci. Lett., 266, 49-52 (1999). 10336181Postnatal locomotion development in a neurological mutant of rolling mouse Nagoya. Tamaki Y, Oda S, Kameyama Y Dev. Psycobiology, 19, 67-77 (1986). 3699253Neurotransmitter receptors of the rolling mouse Nagoya: a quantitative autoradiographic study. Onodera H, Takase S, Oda S, Sobue I, Kogure K Neurosci. Res., 5, 316-324 (1988). 2897649Reduced voltage sensitivity of activation of P/Q-type Ca2+ channels is associated with the ataxic mouse mutation rolling Nagoya (tg(rol)). Mori Y, Wakamori M, Oda S, Fletcher C F, Sekiguchi N, Mori E, Copeland N G, Jenkins N A, Matsushita K, Matsuyama Z, Imoto K J. Neurosci., 20, 5654-5662 (2000). 10908603医学のあゆみ, 101, 74-75 (1977). 実験動物の遺伝的コントロール(富田武,江崎考三郎,早川純一郎,編)ソフトサイエンス社, 東京, pp. 248-259 (1983). 名古屋大学環境医学研究所年報, 26, 7-9 (1975). Genetic Approches to Developmental Neurobiology (TSUKADA Yasuzo, ed), University of Tokyo Press, Tokyo, pp. 171-181 (1982). チャンネル病, 脳の科学(1999年増刊号), 星和書店, 東京, 101-106 (1999). 実験動物, 22, 281-288 (1973). more 5 references名古屋大学環境医学研究所年報, 27, 193-194 (1976). 名古屋大学環境医学研究所年報, 27, 195-197 (1976). Jpn. J. Genet., 56, 295-299 (1981). 名古屋大学環境医学研究所年報, 28, 212-213 (1977). Biomed. Res., 1, 88-90 (1980). |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Cacna1a | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 8 | Cacna1a | rolling Nagoya |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 27 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | |
Research application | Developmental Biology Research Genetics Research Mouse Models for Human Disease Neurobiology Research |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Senichi Oda (Nagoya University) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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Niimi K, Han Y, Zhou Y, Yoshimoto T, Dai F, Teng X, Tian X, Li W, Takahashi E. Blockade of Cav2.1-mediated NMDA receptor signaling disrupts conditioned fear extinction. Behav Brain Res 259 45-9(2014) 24177210 |
Takahashi E, Niimi K, Itakura C. Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya. Behav Brain Res 204(1) 241-5(2009) 19467269 |
Tian X, Zhou Y, Gao L, He G, Jiang W, Li W, Takahashi E. Analysis of ischemic neuronal injury in Cav2.1 channel α1 subunit mutant mice. Biochem Biophys Res Commun 434(1) 60-4(2013) 23545255 |
Goriely S, Molle C, Nguyen M, Albarani V, Haddou NO, Lin R, De Wit D, Flamand V, Willems F, Goldman M. Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation. Blood 107(3) 1078-84(2006) 16219795 |
Kim TY, Niimi K, Takahashi E. Analysis of the protective effects of the α2/δ subunit of voltage-gated Ca2+ channels in brain injury. Brain Res 1655 138-144(2017) 27840189 |
Takahashi E, Niimi K, Itakura C. Motor coordination impairment in aged heterozygous rolling Nagoya, Cav2.1 mutant mice. Brain Res 1279 50-7(2009) 19446536 |
Takahashi E, Niimi K. Spatial learning deficit in aged heterozygous Cav2.1 channel mutant mice, rolling mouse Nagoya. Exp Gerontol 44(4) 274-9(2009) 19073246 |
Takahashi E, Niimi K, Itakura C. Interaction between Ca(v)2.1alpha (1) and CaMKII in Ca (v)2.1alpha (1) mutant mice, Rolling Nagoya. J Mol Neurosci 41(2) 223-9(2010) 19609731 |
Fukumoto N, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I. Ca2+ channel currents in dorsal root ganglion neurons of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya. Neurosci Res 73(3) 199-206(2012) 22575052 |
Fukumoto N, Obama Y, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I. Hypoalgesic behaviors of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya. Neuroscience 160(1) 165-73(2009) 19248821 |