Strain Data Sheet

RBRC00387

Strain Information

Image
BRC No.RBRC00387
TypeSpontaneous Mutation
SpeciesMus musculus
Strain namePIC/Nem-Pdn/+
Former Common namePDN/Nem-Pdn/+
H-2 Haplotype
ES Cell line
Background strain
Appearancealbino [c/c]
Strain development
Strain description
Colony maintenanceSibling Mating (Heterozygote x Wild-type, Heterozygote)
References
Polydactyly Nagoya, Pdn: A new mutant gene in the mouse.
I Hayasaka, T Nakatsuka, T Fujii, I Naruse, S Oda
Exp. Anim., 29, 391-395 (1980). 7202526

Developmental brain abnormalities accompanied with the retarded production of S-100 beta protein in genetic polydactyly mice.
I Naruse, K Kato, T Asano, F Suzuki, Y Kameyama
Dev. Brain. Res., 51, 253-258 (1990). 2323034

Integration of a transposon into the Gli3 gene in the Pdn mouse.
Etsuko Ueta, Eiji Nanba, Ichiro Naruse
Congenital Anomalies, 42, 318-322 (2002). 12634451

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Gli3
MGI:95729		GLI-Kruppel family member GLI313Gli3<Pdn>
MGI:1856282		polydactyly Nagoya
  • Greig cephalopolysyndactyly syndrome(DisGeNET, MedGEN)

  • Pallister-Hall syndrome(DisGeNET, MedGEN)

  • polydactyly, postaxial, type A1(MedGEN)
    • more 1 Diseases
  • polysyndactyly 4(MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal cerebral cortex morphology (MP:0000788)

  • abnormal cerebral hemisphere morphology (MP:0008540)

  • abnormal digit morphology (MP:0002110)

  • abnormal hippocampal fornix morphology (MP:0003006)

  • abnormal hippocampus development (MP:0000808)
    • more 28 phenotypes
  • abnormal hippocampus morphology (MP:0000807)

  • abnormal hippocampus pyramidal cell layer (MP:0008284)

  • abnormal hypothalamus morphology (MP:0000837)

  • abnormal neuronal migration (MP:0006009)

  • abnormal olfactory nerve morphology (MP:0005236)

  • abnormal radial glial cell morphology (MP:0003648)

  • abnormal sternum manubrium morphology (MP:0008785)

  • abnormal sternum morphology (MP:0000157)

  • abnormal stratification in cerebral cortex (MP:0000790)

  • abnormal thalamus morphology (MP:0000832)

  • absent anterior commissure (MP:0008227)

  • absent corpus callosum (MP:0002196)

  • absent hippocampal commissure (MP:0008223)

  • absent olfactory bulb (MP:0003451)

  • absent pineal gland (MP:0013362)

  • cleft palate (MP:0000111)

  • encephalomeningocele (MP:0012260)

  • exencephaly (MP:0000914)

  • eyelids open at birth (MP:0001302)

  • hydrocephaly (MP:0001891)

  • polydactyly (MP:0000562)

  • postnatal lethality (MP:0002082)

  • short fibula (MP:0002765)

  • short tibia (MP:0002764)

  • split sternal manubrium (MP:0012667)

  • spongiform encephalopathy (MP:0002654)

  • synostosis (MP:0000566)

  • thin cerebral cortex (MP:0006254)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDevelopmental Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Congenital Anomalies, 42, 318-322 (2002). Dev, Brain, Res., 51, 253-258 (1990).
    DepositorIchiro Naruse (Tottori University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    Ueta E, Kodama M, Sumino Y, Kurome M, Ohta K, Katagiri R, Naruse I.
    Gender-dependent differences in the incidence of ochratoxin A-induced neural tube defects in the Pdn/Pdn mouse.
    Congenit Anom (Kyoto) 50(1) 29-39(2010) 20201966
    Naruse I, Ueta E, Sumino Y, Ogawa M, Ishikiriyama S.
    Birth defects caused by mutations in human GLI3 and mouse Gli3 genes.
    Congenit Anom (Kyoto) 50(1) 1-7(2010) 20201963
    Imai T, Yamazaki T, Kobayakawa R, Kobayakawa K, Abe T, Suzuki M, Sakano H.
    Pre-target axon sorting establishes the neural map topography.
    Science 325(5940) 585-90(2009) 19589963