Strain Data Sheet

RBRC00387

Strain Information

Image
BRC No.RBRC00387
TypeSpontaneous Mutation
SpeciesMus musculus
Strain namePIC/Nem-Pdn/+
Former Common namePDN/Nem-Pdn/+
H-2 Haplotype
ES Cell line
Background strain
Appearancealbino [c/c]
Strain development
Strain description
Colony maintenanceSibling Mating (Heterozygote x Wild-type, Heterozygote)
References
Developmental brain abnormalities accompanied with the retarded production of S-100 beta protein in genetic polydactyly mice.
Naruse I, Kato K, Asano T, Suzuki F, Kameyama Y
Dev. Brain. Res., 51, 253-258 (1990). 2323034

Integration of a transposon into the Gli3 gene in the Pdn mouse.
Ueta E, Nanba E, Naruse I
Congenital Anomalies, 42, 318-322 (2002). 12634451

Polydactyly Nagoya, Pdn: A new mutant gene in the mouse.
Hayasaka I, Nakatsuka T, Fujii T, Naruse I, Oda S
Exp. Anim., 29, 391-395 (1980). 7202526

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Gli3GLI-Kruppel family member GLI313Gli3polydactyly Nagoya
  • Greig cephalopolysyndactyly syndrome(DisGeNET, MedGEN)

  • Pallister-Hall syndrome(DisGeNET, MedGEN)

  • polydactyly, postaxial, type A1(MedGEN)
  • more 1 Diseases
  • polysyndactyly 4(MedGEN)
  • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal cerebral cortex morphology(MP:0000788)

  • abnormal cerebral hemisphere morphology(MP:0008540)

  • abnormal digit morphology(MP:0002110)

  • abnormal hippocampal fornix morphology(MP:0003006)

  • abnormal hippocampus development(MP:0000808)
  • more 28 phenotypes
  • abnormal hippocampus morphology(MP:0000807)

  • abnormal hippocampus pyramidal cell layer(MP:0008284)

  • abnormal hypothalamus morphology(MP:0000837)

  • abnormal neuronal migration(MP:0006009)

  • abnormal olfactory nerve morphology(MP:0005236)

  • abnormal radial glial cell morphology(MP:0003648)

  • abnormal sternum manubrium morphology(MP:0008785)

  • abnormal sternum morphology(MP:0000157)

  • abnormal stratification in cerebral cortex(MP:0000790)

  • abnormal thalamus morphology(MP:0000832)

  • absent anterior commissure(MP:0008227)

  • absent corpus callosum(MP:0002196)

  • absent hippocampal commissure(MP:0008223)

  • absent olfactory bulb(MP:0003451)

  • absent pineal gland(MP:0013362)

  • cleft palate(MP:0000111)

  • encephalomeningocele(MP:0012260)

  • exencephaly(MP:0000914)

  • eyelids open at birth(MP:0001302)

  • hydrocephaly(MP:0001891)

  • polydactyly(MP:0000562)

  • postnatal lethality(MP:0002082)

  • short fibula(MP:0002765)

  • short tibia(MP:0002764)

  • split sternal manubrium(MP:0012667)

  • spongiform encephalopathy(MP:0002654)

  • synostosis(MP:0000566)

  • thin cerebral cortex(MP:0006254)
  • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDevelopmental Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Congenital Anomalies, 42, 318-322 (2002). Dev, Brain, Res., 51, 253-258 (1990).
    DepositorIchiro Naruse (Tottori University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    Ueta E, Kodama M, Sumino Y, Kurome M, Ohta K, Katagiri R, Naruse I.
    Gender-dependent differences in the incidence of ochratoxin A-induced neural tube defects in the Pdn/Pdn mouse.
    Congenit Anom (Kyoto) 50(1) 29-39(2010) 20201966
    Naruse I, Ueta E, Sumino Y, Ogawa M, Ishikiriyama S.
    Birth defects caused by mutations in human GLI3 and mouse Gli3 genes.
    Congenit Anom (Kyoto) 50(1) 1-7(2010) 20201963
    Imai T, Yamazaki T, Kobayakawa R, Kobayakawa K, Abe T, Suzuki M, Sakano H.
    Pre-target axon sorting establishes the neural map topography.
    Science 325(5940) 585-90(2009) 19589963